From Wikipedia, the free encyclopedia
Jump to navigation Jump to search

CD96 (Cluster of Differentiation 96) or Tactile (T cell activation, increased late expression) is a receptor expressed on T cells and NK cells, and shares sequence similarity with CD226 (also known as DNAM-1).[1] The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein. The protein may play a role in the adhesion of activated T and NK cells to their target cells during the late phase of the immune response. It may also function in antigen presentation[citation needed]. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. CD96 is a transmembrane glycoprotein that has three extracellular immunoglobulin-like domains and is expressed by all resting human and mouse NK cells. CD96 main ligand is CD155. CD 96 has approximately 20% homology with CD226 and competed for binding to CD155 with CD226.[2]


  1. ^ Fuchs, Anja; Colonna, M. (October 2006). "The role of NK cell recognition of nectin and nectin-like proteins in tumor immunosurveillance". Semin. Cancer Biol. 16 (5): 359–366. doi:10.1016/j.semcancer.2006.07.002. PMID 16904340.
  2. ^ Smyth, Mark J.; Martinet, L. (March 2015). "Balancing natural killer cell activation through paired receptors". Nature Reviews Immunology. 15 (4): 243–254. doi:10.1038/nri3799. PMID 25743219.