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Aliases CDC14A, cdc14, hCDC14, cell division cycle 14A, DFNB105
External IDs MGI: 2442676 HomoloGene: 75343 GeneCards: CDC14A
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CDC14A
Genomic location for CDC14A
Band 1p21.2 Start 100,345,001 bp[1]
End 100,520,278 bp[1]
RNA expression pattern
PBB GE CDC14A 210742 at fs.png

PBB GE CDC14A 210743 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 1: 100.35 – 100.52 Mb Chr 3: 116.27 – 116.42 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Dual specificity protein phosphatase CDC14A is an enzyme that in humans is encoded by the CDC14A gene.[5][6][7]

The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms.[7]


CDC14A has been shown to interact with P53.[8]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000079335 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033502 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Li L, Ernsting BR, Wishart MJ, Lohse DL, Dixon JE (December 1997). "A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast". J Biol Chem. 272 (47): 29403–6. doi:10.1074/jbc.272.47.29403. PMID 9367992. 
  6. ^ Wong AK, Chen Y, Lian L, Ha PC, Petersen K, Laity K, Carillo A, Emerson M, Heichman K, Gupte J, Tavtigian SV, Teng DH (September 1999). "Genomic structure, chromosomal location, and mutation analysis of the human CDC14A gene". Genomics. 59 (2): 248–51. doi:10.1006/geno.1999.5863. PMID 10409437. 
  7. ^ a b "Entrez Gene: CDC14A CDC14 cell division cycle 14 homolog A (S. cerevisiae)". 
  8. ^ Li, L; Ljungman M; Dixon J E (January 2000). "The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53". J. Biol. Chem. UNITED STATES. 275 (4): 2410–4. doi:10.1074/jbc.275.4.2410. ISSN 0021-9258. PMID 10644693. 

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