From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
Protein CDC14B PDB 1ohc.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesCDC14B, CDC14B3, Cdc14B1, Cdc14B2, hcell division cycle 14B
External IDsOMIM: 603505 MGI: 2441808 HomoloGene: 104197 GeneCards: CDC14B
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for CDC14B
Genomic location for CDC14B
Band9q22.32-q22.33Start96,490,241 bp[1]
End96,619,830 bp[1]
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC)Chr 9: 96.49 – 96.62 MbChr 13: 64.19 – 64.28 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

Dual specificity protein phosphatase CDC14B is an enzyme that in humans is encoded by the CDC14B gene.[5][6]

The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. Specifically, it is thought to fulfil this role by bundling and stabilising microtubules. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in 3 transcript variants encoding distinct isoforms.[6]


CDC14B has been shown to interact with p53.[7] However, this interaction has not been reported in other studies.


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000081377 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033102 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Li L, Ernsting BR, Wishart MJ, Lohse DL, Dixon JE (December 1997). "A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast". J Biol Chem. 272 (47): 29403–29406. doi:10.1074/jbc.272.47.29403. PMID 9367992.
  6. ^ a b "Entrez Gene: CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae)".
  7. ^ Li, L; Ljungman M; Dixon J E (January 2000). "The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53". J. Biol. Chem. 275 (4): 2410–2414. doi:10.1074/jbc.275.4.2410. ISSN 0021-9258. PMID 10644693.

External links[edit]

Further reading[edit]