CDC14B

CDC14B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1OHC, 1OHD, 1OHE
Identifiers
Aliases	CDC14B, CDC14B3, Cdc14B1, Cdc14B2, hcell division cycle 14B
External IDs	OMIM: 603505; MGI: 2441808; HomoloGene: 104197; GeneCards: CDC14B; OMA:CDC14B - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	96,619,843 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	64,275,290 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; tendon of biceps brachii; ; internal globus pallidus; ; optic nerve; ; retinal pigment epithelium; ; C1 segment; ; gonad; ; inferior ganglion of vagus nerve; ; bronchial epithelial cell; ; seminal vesicula;
	Top expressed in
	hand; ; Epithelium of choroid plexus; ; spermatid; ; primitive streak; ; gastrula; ; maxillary prominence; ; left lobe of liver; ; mandibular prominence; ; tail of embryo; ; atrium;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein tyrosine phosphatase activity; phosphoprotein phosphatase activity; hydrolase activity; protein tyrosine/serine/threonine phosphatase activity; phosphatase activity; protein binding; protein serine/threonine phosphatase activity;
Cellular component	nucleus; nucleolus; cytoplasm; nucleoplasm; spindle pole; centrosome; mitotic spindle;
Biological process	DNA repair; cellular response to DNA damage stimulus; dephosphorylation; protein dephosphorylation; peptidyl-tyrosine dephosphorylation; positive regulation of ubiquitin protein ligase activity; regulation of exit from mitosis; mitotic spindle midzone assembly; cilium assembly; mitotic G2 DNA damage checkpoint signaling; microtubule cytoskeleton organization; mitotic cell cycle; positive regulation of cytokinesis;
	Sources:Amigo / QuickGO
Orthologs
	8555
	218294
	ENSG00000081377
	ENSMUSG00000033102
	O60729
	Q6PFY9
NM_001077181; NM_003671; NM_033331; NM_033332; NM_001351567;
	NM_001351568; NM_001351569; NM_001351570
	NM_001122989; NM_172587
NP_001070649; NP_003662; NP_201588; NP_001338496; NP_001338497;
	NP_001338498; NP_001338499
	NP_001116461; NP_766175
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity protein phosphatase CDC14B is an enzyme that in humans is encoded by the CDC14B gene.^[5]^[6]

Template:PBB Summary

Interactions

CDC14B has been shown to interact with p53.^[7] However, this interaction has not been reported in other studies.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000081377 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033102 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Li L, Ernsting BR, Wishart MJ, Lohse DL, Dixon JE (December 1997). "A family of putative tumor suppressors is structurally and functionally conserved in humans and yeast". J Biol Chem. 272 (47): 29403–29406. doi:10.1074/jbc.272.47.29403. PMID 9367992.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: CDC14B CDC14 cell division cycle 14 homolog B (S. cerevisiae)".
^ Li, L; Ljungman M; Dixon J E (January 2000). "The human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53". J. Biol. Chem. 275 (4). UNITED STATES: 2410–2414. doi:10.1074/jbc.275.4.2410. ISSN 0021-9258. PMID 10644693. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)CS1 maint: unflagged free DOI (link)

Interactions

References

Further reading