CDC23

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CDC23
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCDC23, ANAPC8, APC8, CUT23, cell division cycle 23
External IDsMGI: 1098815 HomoloGene: 3426 GeneCards: CDC23
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for CDC23
Genomic location for CDC23
Band5q31.2Start138,187,648 bp[1]
End138,213,343 bp[1]
RNA expression pattern
PBB GE CDC23 202892 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004661

NM_178347

RefSeq (protein)

NP_004652

NP_848124

Location (UCSC)Chr 5: 138.19 – 138.21 MbChr 18: 34.63 – 34.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cell division cycle 23 homolog (S. cerevisiae), also known as CDC23, is a protein that, in humans, is encoded by the CDC23 gene.[5]

Function[edit]

The CDC23 protein shares strong similarity with Saccharomyces cerevisiae Cdc23, a protein essential for cell cycle progression through the G2/M transition. This protein is a component of anaphase-promoting complex (APC), which is composed of eight protein subunits and highly conserved in eukaryotic cells. APC catalyzes the formation of cyclin B-ubiquitin conjugate that is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. This protein and 3 other members of the APC complex contain the TPR (tetratricopeptide repeat), a protein domain important for protein-protein interaction.[5]

Interactions[edit]

CDC23 has been shown to interact with CDC27.[6][7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000094880 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024370 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: CDC23 cell division cycle 23 homolog (S. cerevisiae)". 
  6. ^ Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (Sep 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1". Current Biology. 13 (17): 1459–68. doi:10.1016/S0960-9822(03)00581-5. PMID 12956947. 
  7. ^ Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (Aug 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (16): 8973–8. doi:10.1073/pnas.97.16.8973. PMC 16806Freely accessible. PMID 10922056. 

External links[edit]

Further reading[edit]