CDC25C

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CDC25C
Protein CDC25C PDB 3BZI.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CDC25C, CDC25, PPP1R60, cell division cycle 25C
External IDs MGI: 88350 HomoloGene: 1356 GeneCards: CDC25C
Gene location (Human)
Chromosome 5 (human)
Chr. Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for CDC25C
Genomic location for CDC25C
Band 5q31.2 Start 138,285,265 bp[1]
End 138,338,355 bp[1]
RNA expression pattern
PBB GE CDC25C 217010 s at fs.png

PBB GE CDC25C 205167 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001287582
NM_001287583
NM_001790
NM_022809
NM_001318098

NM_009860

RefSeq (protein)

NP_001274511
NP_001274512
NP_001305027
NP_001781
NP_073720

NP_033990

Location (UCSC) Chr 5: 138.29 – 138.34 Mb Chr 5: 34.73 – 34.75 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

M-phase inducer phosphatase 3 is an enzyme that in humans is encoded by the CDC25C gene.[5]

This gene is highly conserved during evolution and it plays a key role in the regulation of cell division. The encoded protein is a tyrosine phosphatase and belongs to the Cdc25 phosphatase family. It directs dephosphorylation of cyclin B-bound CDC2 (CDK1) and triggers entry into mitosis. It is also thought to suppress p53-induced growth arrest. Multiple alternatively spliced transcript variants of this gene have been described, however, the full-length nature of many of them is not known.[6]

Interactions[edit]

CDC25C has been shown to interact with MAPK14,[7] CHEK1,[8] PCNA,[9] PIN1,[10][11][12] PLK3[13] and NEDD4.[12]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158402 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044201 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Gould KL, Moreno S, Tonks NK, Nurse P (Feb 1991). "Complementation of the mitotic activator, p80cdc25, by a human protein-tyrosine phosphatase". Science. 250 (4987): 1573–6. PMID 1703321. doi:10.1126/science.1703321. 
  6. ^ "Entrez Gene: CDC25C cell division cycle 25 homolog C (S. pombe)". 
  7. ^ Bulavin, D V; Higashimoto Y; Popoff I J; Gaarde W A; Basrur V; Potapova O; Appella E; Fornace A J (May 2001). "Initiation of a G2/M checkpoint after ultraviolet radiation requires p38 kinase". Nature. England. 411 (6833): 102–7. ISSN 0028-0836. PMID 11333986. doi:10.1038/35075107. 
  8. ^ Sanchez, Y; Wong C; Thoma R S; Richman R; Wu Z; Piwnica-Worms H; Elledge S J (Sep 1997). "Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25". Science. UNITED STATES. 277 (5331): 1497–501. ISSN 0036-8075. PMID 9278511. doi:10.1126/science.277.5331.1497. 
  9. ^ Kawabe, Takumi; Suganuma Masashi; Ando Tomoaki; Kimura Mayumi; Hori Haruna; Okamoto Takashi (Mar 2002). "Cdc25C interacts with PCNA at G2/M transition". Oncogene. England. 21 (11): 1717–26. ISSN 0950-9232. PMID 11896603. doi:10.1038/sj.onc.1205229. 
  10. ^ Shen, M; Stukenberg P T; Kirschner M W; Lu K P (Mar 1998). "The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins". Genes Dev. UNITED STATES. 12 (5): 706–20. ISSN 0890-9369. PMC 316589Freely accessible. PMID 9499405. doi:10.1101/gad.12.5.706. 
  11. ^ Goldstrohm, A C; Albrecht T R; Suñé C; Bedford M T; Garcia-Blanco M A (Nov 2001). "The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1". Mol. Cell. Biol. United States. 21 (22): 7617–28. ISSN 0270-7306. PMC 99933Freely accessible. PMID 11604498. doi:10.1128/MCB.21.22.7617-7628.2001. 
  12. ^ a b Lu, P J; Zhou X Z; Shen M; Lu K P (Feb 1999). "Function of WW domains as phosphoserine- or phosphothreonine-binding modules". Science. UNITED STATES. 283 (5406): 1325–8. ISSN 0036-8075. PMID 10037602. doi:10.1126/science.283.5406.1325. 
  13. ^ Ouyang, B; Li W; Pan H; Meadows J; Hoffmann I; Dai W (Oct 1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk". Oncogene. ENGLAND. 18 (44): 6029–36. ISSN 0950-9232. PMID 10557092. doi:10.1038/sj.onc.1202983. 

External links[edit]

Further reading[edit]