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Aliases CDK11A, CDC2L2, CDC2L3, CDK11-p110, CDK11-p46, CDK11-p58, PITSLRE, p58GTA, cyclin-dependent kinase 11A, cyclin dependent kinase 11A
External IDs MGI: 88353 HomoloGene: 22416 GeneCards: CDK11A
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)



Location (UCSC) Chr 1: 1.7 – 1.72 Mb Chr 4: 155.62 – 155.65 Mb
PubMed search [1] [2]
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PITSLRE serine/threonine-protein kinase CDC2L2 is an enzyme that in humans is encoded by the CDC2L2 gene.[3][4][5]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Lahti JM, Valentine M, Xiang J, Jones B, Amann J, Grenet J, Richmond G, Look AT, Kidd VJ (July 1994). "Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma". Nature Genetics. 7 (3): 370–5. doi:10.1038/ng0794-370. PMID 7920654. 
  4. ^ Gururajan R, Lahti JM, Grenet J, Easton J, Gruber I, Ambros PF, Kidd VJ (September 1998). "Duplication of a genomic region containing the Cdc2L1-2 and MMP21-22 genes on human chromosome 1p36.3 and their linkage to D1Z2". Genome Research. 8 (9): 929–39. doi:10.1101/gr.8.9.929. PMC 310781Freely accessible. PMID 9750192. 
  5. ^ "Entrez Gene: LOC728642 similar to cell division cycle 2-like 1 (PITSLRE proteins) isoform 1". 

External links[edit]

Further reading[edit]

  • Eipers PG, Lahti JM, Kidd VJ (July 1992). "Structure and expression of the human p58clk-1 protein kinase chromosomal gene". Genomics. 13 (3): 613–21. doi:10.1016/0888-7543(92)90132-C. PMID 1639388. 
  • Eipers PG, Barnoski BL, Han J, Carroll AJ, Kidd VJ (November 1991). "Localization of the expressed human p58 protein kinase chromosomal gene to chromosome 1p36 and a highly related sequence to chromosome 15". Genomics. 11 (3): 621–9. doi:10.1016/0888-7543(91)90069-Q. PMID 1774066. 
  • Bunnell BA, Heath LS, Adams DE, Lahti JM, Kidd VJ (October 1990). "Increased expression of a 58-kDa protein kinase leads to changes in the CHO cell cycle". Proceedings of the National Academy of Sciences of the United States of America. 87 (19): 7467–71. doi:10.1073/pnas.87.19.7467. PMC 54768Freely accessible. PMID 2217177. 
  • White PS, Maris JM, Beltinger C, Sulman E, Marshall HN, Fujimori M, Kaufman BA, Biegel JA, Allen C, Hilliard C, Valentine MB, Look AT, Enomoto H, Sakiyama S, Brodeur GM (June 1995). "A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3". Proceedings of the National Academy of Sciences of the United States of America. 92 (12): 5520–4. doi:10.1073/pnas.92.12.5520. PMC 41727Freely accessible. PMID 7777541. 
  • Xiang J, Lahti JM, Grenet J, Easton J, Kidd VJ (June 1994). "Molecular cloning and expression of alternatively spliced PITSLRE protein kinase isoforms". The Journal of Biological Chemistry. 269 (22): 15786–94. PMID 8195233. 
  • Beyaert R, Kidd VJ, Cornelis S, Van de Craen M, Denecker G, Lahti JM, Gururajan R, Vandenabeele P, Fiers W (May 1997). "Cleavage of PITSLRE kinases by ICE/CASP-1 and CPP32/CASP-3 during apoptosis induced by tumor necrosis factor". The Journal of Biological Chemistry. 272 (18): 11694–7. doi:10.1074/jbc.272.18.11694. PMID 9115219. 
  • Loyer P, Trembley JH, Lahti JM, Kidd VJ (June 1998). "The RNP protein, RNPS1, associates with specific isoforms of the p34cdc2-related PITSLRE protein kinase in vivo". Journal of Cell Science. 111 ( Pt 11) (11): 1495–506. PMID 9580558. 
  • Tang D, Gururajan R, Kidd VJ (June 1998). "Phosphorylation of PITSLRE p110 isoforms accompanies their processing by caspases during Fas-mediated cell death". The Journal of Biological Chemistry. 273 (26): 16601–7. doi:10.1074/jbc.273.26.16601. PMID 9632733. 
  • Gururajan R, Grenet J, Lahti JM, Kidd VJ (August 1998). "Isolation and characterization of two novel metalloproteinase genes linked to the Cdc2L locus on human chromosome 1p36.3". Genomics. 52 (1): 101–6. doi:10.1006/geno.1998.5401. PMID 9740677. 
  • Cornelis S, Bruynooghe Y, Denecker G, Van Huffel S, Tinton S, Beyaert R (April 2000). "Identification and characterization of a novel cell cycle-regulated internal ribosome entry site". Molecular Cell. 5 (4): 597–605. doi:10.1016/S1097-2765(00)80239-7. PMID 10882096. 
  • Zhang SW, Xu SL, Cai MM, Yan J, Zhu XY, Hu Y, Gu JX (May 2001). "Effect of p58GTA on beta-1,4-galactosyltransferase 1 activity and cell-cycle in human hepatocarcinoma cells". Molecular and Cellular Biochemistry. 221 (1-2): 161–8. doi:10.1023/A:1010932211745. PMID 11506180. 
  • Berke JD, Sgambato V, Zhu PP, Lavoie B, Vincent M, Krause M, Hyman SE (October 2001). "Dopamine and glutamate induce distinct striatal splice forms of Ania-6, an RNA polymerase II-associated cyclin". Neuron. 32 (2): 277–87. doi:10.1016/S0896-6273(01)00465-2. PMID 11683997. 
  • Dickinson LA, Edgar AJ, Ehley J, Gottesfeld JM (July 2002). "Cyclin L is an RS domain protein involved in pre-mRNA splicing". The Journal of Biological Chemistry. 277 (28): 25465–73. doi:10.1074/jbc.M202266200. PMID 11980906. 
  • Shi J, Feng Y, Goulet AC, Vaillancourt RR, Sachs NA, Hershey JW, Nelson MA (February 2003). "The p34cdc2-related cyclin-dependent kinase 11 interacts with the p47 subunit of eukaryotic initiation factor 3 during apoptosis". The Journal of Biological Chemistry. 278 (7): 5062–71. doi:10.1074/jbc.M206427200. PMID 12446680. 
  • Hu D, Mayeda A, Trembley JH, Lahti JM, Kidd VJ (March 2003). "CDK11 complexes promote pre-mRNA splicing". The Journal of Biological Chemistry. 278 (10): 8623–9. doi:10.1074/jbc.M210057200. PMID 12501247. 
  • Chen S, Yin X, Zhu X, Yan J, Ji S, Chen C, Cai M, Zhang S, Zong H, Hu Y, Yuan Z, Shen Z, Gu J (May 2003). "The C-terminal kinase domain of the p34cdc2-related PITSLRE protein kinase (p110C) associates with p21-activated kinase 1 and inhibits its activity during anoikis". The Journal of Biological Chemistry. 278 (22): 20029–36. doi:10.1074/jbc.M300818200. PMID 12624090.