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Protein CDC34 PDB 2ob4.png
Available structures
PDBOrtholog search: PDBe RCSB
AliasesCDC34, E2-UBC3, UBCH3, UBE2R1, cell division cycle 34
External IDsOMIM: 116948 MGI: 102657 HomoloGene: 55815 GeneCards: CDC34
EC number2.3.2.24
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for CDC34
Genomic location for CDC34
Band19p13.3Start531,760 bp[1]
End542,092 bp[1]
RNA expression pattern
PBB GE CDC34 212540 at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC)Chr 19: 0.53 – 0.54 MbChr 10: 79.68 – 79.69 Mb
PubMed search[3][4]
View/Edit HumanView/Edit Mouse

CDC34 is a gene encoding a protein product that has ubiquitin conjugating activity. CDC34 was originally discovered by work in baker's yeast as a gene that has a role in the cell division cycle. Cdc34 in yeast targets numerous substrates (Sic1, Far1, Cln1, Cln2) for ubiquitin mediated degradation. Ubiquitin-conjugating enzyme E2 R1 is a protein that in humans is encoded by the CDC34 gene.[5][6][7]

The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication.[7]


CDC34 has been shown to interact with CSNK2B,[8] BTRC[9][10] and CDK9.[11]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000099804 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020307 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Plon SE, Leppig KA, Do HN, Groudine M (Dec 1993). "Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast". Proc Natl Acad Sci U S A. 90 (22): 10484–8. Bibcode:1993PNAS...9010484P. doi:10.1073/pnas.90.22.10484. PMC 47801. PMID 8248134.
  6. ^ Gazdoiu S, Yamoah K, Wu K, Escalante CR, Tappin I, Bermudez V, Aggarwal AK, Hurwitz J, Pan ZQ (Oct 2005). "Proximity-induced activation of human Cdc34 through heterologous dimerization". Proc Natl Acad Sci U S A. 102 (42): 15053–8. Bibcode:2005PNAS..10215053G. doi:10.1073/pnas.0507646102. PMC 1242854. PMID 16210246.
  7. ^ a b "Entrez Gene: CDC34 cell division cycle 34 homolog (S. cerevisiae)".
  8. ^ Block, K; Boyer T G; Yew P R (Nov 2001). "Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2". J. Biol. Chem. United States. 276 (44): 41049–58. doi:10.1074/jbc.M106453200. ISSN 0021-9258. PMID 11546811.
  9. ^ Semplici, Francesca; Meggio Flavio; Pinna Lorenzo A; Oliviero Salvatore (Jun 2002). "CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation". Oncogene. England. 21 (25): 3978–87. doi:10.1038/sj.onc.1205574. ISSN 0950-9232. PMID 12037680.
  10. ^ Cenciarelli, C; Chiaur D S; Guardavaccaro D; Parks W; Vidal M; Pagano M (Oct 1999). "Identification of a family of human F-box proteins". Curr. Biol. ENGLAND. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. ISSN 0960-9822. PMID 10531035.
  11. ^ Kiernan, R E; Emiliani S; Nakayama K; Castro A; Labbé J C; Lorca T; Nakayama Ki K; Benkirane M (Dec 2001). "Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome". Mol. Cell. Biol. United States. 21 (23): 7956–70. doi:10.1128/MCB.21.23.7956-7970.2001. ISSN 0270-7306. PMC 99964. PMID 11689688.

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