CDC34

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CDC34
Protein CDC34 PDB 2ob4.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CDC34, E2-UBC3, UBCH3, UBE2R1, cell division cycle 34
External IDs MGI: 102657 HomoloGene: 55815 GeneCards: 997
EC number 2.3.2.24
RNA expression pattern
PBB GE CDC34 212540 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004359

NM_177613

RefSeq (protein)

NP_004350.1

NP_808281.1

Location (UCSC) Chr 19: 0.53 – 0.54 Mb Chr 10: 79.68 – 79.69 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

CDC34 is a gene encoding a protein product that has ubiquitin conjugating activity. CDC34 was originally discovered by work in baker's yeast as a gene that has a role in the cell division cycle. Cdc34 in yeast targets numerous substrates (Sic1, Far1, Cln1, Cln2) for ubiquitin mediated degradation. Ubiquitin-conjugating enzyme E2 R1 is a protein that in humans is encoded by the CDC34 gene.[1][2][3]

The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication.[3]

Interactions[edit]

CDC34 has been shown to interact with CSNK2B,[4] BTRC[5][6] and CDK9.[7]

References[edit]

  1. ^ Plon SE, Leppig KA, Do HN, Groudine M (Dec 1993). "Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast". Proc Natl Acad Sci U S A 90 (22): 10484–8. doi:10.1073/pnas.90.22.10484. PMC 47801. PMID 8248134. 
  2. ^ Gazdoiu S, Yamoah K, Wu K, Escalante CR, Tappin I, Bermudez V, Aggarwal AK, Hurwitz J, Pan ZQ (Oct 2005). "Proximity-induced activation of human Cdc34 through heterologous dimerization". Proc Natl Acad Sci U S A 102 (42): 15053–8. doi:10.1073/pnas.0507646102. PMC 1242854. PMID 16210246. 
  3. ^ a b "Entrez Gene: CDC34 cell division cycle 34 homolog (S. cerevisiae)". 
  4. ^ Block, K; Boyer T G; Yew P R (Nov 2001). "Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2". J. Biol. Chem. (United States) 276 (44): 41049–58. doi:10.1074/jbc.M106453200. ISSN 0021-9258. PMID 11546811. 
  5. ^ Semplici, Francesca; Meggio Flavio; Pinna Lorenzo A; Oliviero Salvatore (Jun 2002). "CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation". Oncogene (England) 21 (25): 3978–87. doi:10.1038/sj.onc.1205574. ISSN 0950-9232. PMID 12037680. 
  6. ^ Cenciarelli, C; Chiaur D S; Guardavaccaro D; Parks W; Vidal M; Pagano M (Oct 1999). "Identification of a family of human F-box proteins". Curr. Biol. (ENGLAND) 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. ISSN 0960-9822. PMID 10531035. 
  7. ^ Kiernan, R E; Emiliani S; Nakayama K; Castro A; Labbé J C; Lorca T; Nakayama Ki K; Benkirane M (Dec 2001). "Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome". Mol. Cell. Biol. (United States) 21 (23): 7956–70. doi:10.1128/MCB.21.23.7956-7970.2001. ISSN 0270-7306. PMC 99964. PMID 11689688. 

Further reading[edit]