CDC40

From Wikipedia, the free encyclopedia
Jump to: navigation, search
CDC40
Identifiers
Aliases CDC40, EHB3, PRP17, PRPF17, cell division cycle 40
External IDs MGI: 1918963 HomoloGene: 5716 GeneCards: CDC40
RNA expression pattern
PBB GE CDC40 203377 s at fs.png

PBB GE CDC40 203376 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015891

NM_027879

RefSeq (protein)

NP_056975

NP_082155.1
NP_082155

Location (UCSC) Chr 6: 110.18 – 110.25 Mb Chr 10: 40.83 – 40.88 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Pre-mRNA-processing factor 17 is a protein that in humans is encoded by the CDC40 gene.[3][4][5]

Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Ben Yehuda S, Dix I, Russell CS, Levy S, Beggs JD, Kupiec M (Oct 1998). "Identification and functional analysis of hPRP17, the human homologue of the PRP17/CDC40 yeast gene involved in splicing and cell cycle control". RNA. 4 (10): 1304–12. doi:10.1017/S1355838298980712. PMC 1369702Freely accessible. PMID 9769104. 
  4. ^ Lindsey LA, Garcia-Blanco MA (Jan 1999). "Functional conservation of the human homolog of the yeast pre-mRNA splicing factor Prp17p". J Biol Chem. 273 (49): 32771–5. doi:10.1074/jbc.273.49.32771. PMID 9830021. 
  5. ^ a b "Entrez Gene: CDC40 cell division cycle 40 homolog (S. cerevisiae)". 

External links[edit]

Further reading[edit]