CDC42BPA

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CDC42BPA
Identifiers
Aliases CDC42BPA, MRCK, MRCKA, PK428, CDC42 binding protein kinase alpha
External IDs MGI: 2441841 HomoloGene: 55765 GeneCards: CDC42BPA
RNA expression pattern
Gene expression pattern of the CDC42BPA gene.png

PBB GE CDC42BPA 213595 s at fs.png

PBB GE CDC42BPA 203794 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003607
NM_014826

NM_001033285
NM_001346804
NM_001346805

RefSeq (protein)

NP_003598
NP_055641

NP_001028457
NP_001333733
NP_001333734

Location (UCSC) Chr 1: 226.99 – 227.32 Mb Chr 1: 179.96 – 180.17 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase MRCK alpha is an enzyme that in humans is encoded by the CDC42BPA gene.[3]

The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported.[3]

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