CDC42BPA

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
CDC42BPA
Identifiers
AliasesCDC42BPA, MRCK, MRCKA, PK428, CDC42 binding protein kinase alpha
External IDsMGI: 2441841 HomoloGene: 55765 GeneCards: CDC42BPA
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CDC42BPA
Genomic location for CDC42BPA
Band1q42.13Start226,989,865 bp[1]
End227,318,474 bp[1]
RNA expression pattern
Gene expression pattern of the CDC42BPA gene.png

PBB GE CDC42BPA 213595 s at fs.png

PBB GE CDC42BPA 203794 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003607
NM_014826
NM_001366010
NM_001366011
NM_001366019

RefSeq (protein)

NP_003598
NP_055641
NP_001352939
NP_001352940
NP_001352948

Location (UCSC)Chr 1: 226.99 – 227.32 MbChr 1: 179.96 – 180.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase MRCK alpha is an enzyme that in humans is encoded by the CDC42BPA gene.[5]

The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported.[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143776 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026490 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)".

External links[edit]

Further reading[edit]