CDC45-related protein

From Wikipedia, the free encyclopedia
Jump to navigation Jump to search
CDC45
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CDC45, CDC45L, CDC45L2, PORC-PI-1, CDC45-related protein, cell division cycle 45, MGORS7
External IDs MGI: 1338073 HomoloGene: 2616 GeneCards: CDC45
Gene location (Human)
Chromosome 22 (human)
Chr. Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for CDC45
Genomic location for CDC45
Band 22q11.21 Start 19,479,459 bp[1]
End 19,520,612 bp[1]
RNA expression pattern
PBB GE CDC45L 204126 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001178010
NM_001178011
NM_003504

NM_001161623
NM_009862
NM_001358206

RefSeq (protein)

NP_001171481
NP_001171482
NP_003495

NP_001155095
NP_033992
NP_001345135

Location (UCSC) Chr 22: 19.48 – 19.52 Mb Chr 16: 18.78 – 18.81 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CDC45 is a protein that in humans is encoded by the CDC45L gene.[5][6][7][8]

Function[edit]

The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Multiple polyadenlyation sites of this gene are reported.[8]

Interactions[edit]

CDC45-related protein has been shown to interact with:

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000093009 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000028 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Saha P, Thome KC, Yamaguchi R, Hou Z, Weremowicz S, Dutta A (Aug 1998). "The human homolog of Saccharomyces cerevisiae CDC45". J. Biol. Chem. 273 (29): 18205–9. doi:10.1074/jbc.273.29.18205. PMID 9660782. 
  6. ^ McKie JM, Wadey RB, Sutherland HF, Taylor CL, Scambler PJ (Sep 1998). "Direct selection of conserved cDNAs from the DiGeorge critical region: isolation of a novel CDC45-like gene". Genome Res. 8 (8): 834–41. doi:10.1101/gr.8.8.834. PMC 310757Freely accessible. PMID 9724329. 
  7. ^ Pollok S, Bauerschmidt C, Sänger J, Nasheuer HP, Grosse F (Jul 2007). "Human Cdc45 is a proliferation-associated antigen". FEBS J. 274 (14): 3669–84. doi:10.1111/j.1742-4658.2007.05900.x. PMID 17608804. 
  8. ^ a b "Entrez Gene: CDC45L CDC45 cell division cycle 45-like (S. cerevisiae)". 
  9. ^ a b c d e Kneissl M, Pütter V, Szalay AA, Grummt F (Mar 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. 327 (1): 111–28. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612. 
  10. ^ Kukimoto I, Igaki H, Kanda T (Nov 1999). "Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha". Eur. J. Biochem. 265 (3): 936–43. doi:10.1046/j.1432-1327.1999.00791.x. PMID 10518787. 

Further reading[edit]

External links[edit]