CDCA8

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CDCA8
Protein CDCA8 PDB 2KDD.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CDCA8, BOR, BOREALIN, DasraB, MESRGP, cell division cycle associated 8
External IDs MGI: 1196274 HomoloGene: 23075 GeneCards: CDCA8
RNA expression pattern
PBB GE CDCA8 221520 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018101
NM_001256875

NM_026560

RefSeq (protein)

NP_001243804
NP_060571

NP_080836.3
NP_080836

Location (UCSC) Chr 1: 37.69 – 37.71 Mb Chr 4: 124.92 – 124.94 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Borealin is a protein that in humans is encoded by the CDCA8 gene.[3][4][5]

Function[edit]

CDCA8 is a component of a chromosomal passenger complex required for stability of the bipolar mitotic spindle.[5][6]

Interactions[edit]

CDCA8 has been shown to interact with INCENP,[6] Survivin[4][6] and Aurora B kinase.[4][6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Walker MG (May 2001). "Drug target discovery by gene expression analysis: cell cycle genes". Current Cancer Drug Targets. 1 (1): 73–83. doi:10.2174/1568009013334241. PMID 12188893. 
  4. ^ a b c Sampath SC, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H (Jul 2004). "The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly". Cell. 118 (2): 187–202. doi:10.1016/j.cell.2004.06.026. PMID 15260989. 
  5. ^ a b "Entrez Gene: CDCA8 cell division cycle associated 8". 
  6. ^ a b c d Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC (Jul 2004). "Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle". The Journal of Cell Biology. 166 (2): 179–91. doi:10.1083/jcb.200404001. PMC 2172304Freely accessible. PMID 15249581. 

External links[edit]

Further reading[edit]