CDH12

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CDH12
Identifiers
Aliases CDH12, CDHB, cadherin 12
External IDs MGI: 109503 HomoloGene: 37873 GeneCards: 1010
RNA expression pattern
PBB GE CDH12 207149 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004061
NM_001317227
NM_001317228

NM_001008420

RefSeq (protein)

NP_004052.2
NP_001304156.1
NP_001304157.1

NP_001008420.1

Location (UCSC) Chr 5: 21.75 – 22.85 Mb Chr 15: 21.11 – 21.59 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cadherin-12 is a protein that in humans is encoded by the CDH12 gene.[1][2]

This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of an HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.[2]

References[edit]

  1. ^ Selig S, Bruno S, Scharf JM, Wang CH, Vitale E, Gilliam TC, Kunkel LM (Jun 1995). "Expressed cadherin pseudogenes are localized to the critical region of the spinal muscular atrophy gene". Proc Natl Acad Sci U S A 92 (9): 3702–6. doi:10.1073/pnas.92.9.3702. PMC 42029. PMID 7731968. 
  2. ^ a b "Entrez Gene: CDH12 cadherin 12, type 2 (N-cadherin 2)". 

Further reading[edit]

External links[edit]