CDH12

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CDH12
Identifiers
AliasesCDH12, CDHB, cadherin 12
External IDsMGI: 109503 HomoloGene: 37873 GeneCards: CDH12
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for CDH12
Genomic location for CDH12
Band5p14.3Start21,750,673 bp[1]
End22,853,622 bp[1]
RNA expression pattern
PBB GE CDH12 207149 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004061
NM_001317227
NM_001317228

NM_001008420

RefSeq (protein)

NP_001008420

Location (UCSC)Chr 5: 21.75 – 22.85 MbChr 15: 20.45 – 21.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cadherin-12 is a protein that in humans is encoded by the CDH12 gene.[5][6]

This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of an HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154162 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040452 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Selig S, Bruno S, Scharf JM, Wang CH, Vitale E, Gilliam TC, Kunkel LM (Jun 1995). "Expressed cadherin pseudogenes are localized to the critical region of the spinal muscular atrophy gene". Proc Natl Acad Sci U S A. 92 (9): 3702–6. doi:10.1073/pnas.92.9.3702. PMC 42029. PMID 7731968.
  6. ^ a b "Entrez Gene: CDH12 cadherin 12, type 2 (N-cadherin 2)".

Further reading[edit]

External links[edit]