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Cadherin 12, type 2 (N-cadherin 2)
Symbols CDH12 ; CDHB
External IDs OMIM600562 MGI109503 HomoloGene37873 GeneCards: CDH12 Gene
RNA expression pattern
PBB GE CDH12 207149 at tn.png
More reference expression data
Species Human Mouse
Entrez 1010 215654
Ensembl ENSG00000154162 ENSMUSG00000040452
UniProt P55289 Q5RJH3
RefSeq (mRNA) NM_004061 NM_001008420
RefSeq (protein) NP_004052 NP_001008420
Location (UCSC) Chr 5:
21.75 – 22.85 Mb
Chr 15:
21.11 – 21.59 Mb
PubMed search [1] [2]

Cadherin-12 is a protein that in humans is encoded by the CDH12 gene.[1][2]

This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of an HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.[2]


  1. ^ Selig S, Bruno S, Scharf JM, Wang CH, Vitale E, Gilliam TC, Kunkel LM (Jun 1995). "Expressed cadherin pseudogenes are localized to the critical region of the spinal muscular atrophy gene". Proc Natl Acad Sci U S A 92 (9): 3702–6. doi:10.1073/pnas.92.9.3702. PMC 42029. PMID 7731968. 
  2. ^ a b "Entrez Gene: CDH12 cadherin 12, type 2 (N-cadherin 2)". 

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