CDH12

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CDH12
Identifiers
Aliases CDH12, CDHB, cadherin 12
External IDs MGI: 109503 HomoloGene: 37873 GeneCards: 1010
RNA expression pattern
PBB GE CDH12 207149 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004061
NM_001317227
NM_001317228

NM_001008420

RefSeq (protein)

NP_004052.2
NP_001304156.1
NP_001304157.1

NP_001008420.1

Location (UCSC) Chr 5: 21.75 – 22.85 Mb Chr 15: 21.11 – 21.59 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cadherin-12 is a protein that in humans is encoded by the CDH12 gene.[3][4]

This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of an HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.[4]

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