CDH15

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CDH15
Identifiers
Aliases CDH15, CDH14, CDH3, CDHM, MCAD, MRD3, cadherin 15
External IDs MGI: 106672 HomoloGene: 3622 GeneCards: CDH15
RNA expression pattern
PBB GE CDH15 206327 s at tn.png

PBB GE CDH15 206328 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004933

NM_007662

RefSeq (protein)

NP_004924.1

NP_031688.2

Location (UCSC) Chr 16: 89.17 – 89.2 Mb Chr 8: 122.85 – 122.87 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cadherin-15 is a protein that in humans is encoded by the CDH15 gene.[3][4]

Function[edit]

This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation.[4]

Interactions[edit]

CDH15 has been shown to interact with ARVCF.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A (December 1992). "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species". Genomics. 14 (2): 488–90. doi:10.1016/S0888-7543(05)80247-2. PMID 1427864. 
  4. ^ a b "Entrez Gene: CDH15 cadherin 15, M-cadherin (myotubule)". 
  5. ^ Kaufmann U, Zuppinger C, Waibler Z, Rudiger M, Urbich C, Martin B, Jockusch BM, Eppenberger H, Starzinski-Powitz A (November 2000). "The armadillo repeat region targets ARVCF to cadherin-based cellular junctions". J. Cell. Sci. 113 (22): 4121–35. PMID 11058098. 

Further reading[edit]

External links[edit]