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Cadherin 15, type 1, M-cadherin (myotubule)
Symbols CDH15 ; CDH14; CDH3; CDHM; MCAD; MRD3
External IDs OMIM114019 MGI106672 HomoloGene3622 GeneCards: CDH15 Gene
RNA expression pattern
PBB GE CDH15 206327 s at tn.png
PBB GE CDH15 206328 at tn.png
More reference expression data
Species Human Mouse
Entrez 1013 12555
Ensembl ENSG00000129910 ENSMUSG00000031962
UniProt P55291 P33146
RefSeq (mRNA) NM_004933 NM_007662
RefSeq (protein) NP_004924 NP_031688
Location (UCSC) Chr 16:
89.17 – 89.2 Mb
Chr 8:
122.85 – 122.87 Mb
PubMed search [1] [2]

Cadherin-15 is a protein that in humans is encoded by the CDH15 gene.[1][2]


This gene is a member of the cadherin superfamily of genes, encoding calcium-dependent intercellular adhesion glycoproteins. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. The protein is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation.[2]


CDH15 has been shown to interact with ARVCF.[3]


  1. ^ Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A (December 1992). "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species". Genomics 14 (2): 488–90. doi:10.1016/S0888-7543(05)80247-2. PMID 1427864. 
  2. ^ a b "Entrez Gene: CDH15 cadherin 15, M-cadherin (myotubule)". 
  3. ^ Kaufmann U, Zuppinger C, Waibler Z, Rudiger M, Urbich C, Martin B, Jockusch BM, Eppenberger H, Starzinski-Powitz A (November 2000). "The armadillo repeat region targets ARVCF to cadherin-based cellular junctions". J. Cell. Sci. 113 (22): 4121–35. PMID 11058098. 

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