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Cadherin 17, LI cadherin (liver-intestine)
Symbols CDH17 ; CDH16; HPT-1; HPT1
External IDs OMIM603017 MGI1095414 HomoloGene56859 GeneCards: CDH17 Gene
RNA expression pattern
PBB GE CDH17 209847 at tn.png
More reference expression data
Species Human Mouse
Entrez 1015 12557
Ensembl ENSG00000079112 ENSMUSG00000028217
UniProt Q12864 Q9R100
RefSeq (mRNA) NM_001144663 NM_019753
RefSeq (protein) NP_001138135 NP_062727
Location (UCSC) Chr 8:
94.13 – 94.22 Mb
Chr 4:
11.76 – 11.82 Mb
PubMed search [1] [2]

Cadherin-17 is a protein that in humans is encoded by the CDH17 gene.[1][2][3]

This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. The encoded protein is cadherin-like, consisting of an extracellular region, containing 7 cadherin domains, and a transmembrane region but lacking the conserved cytoplasmic domain. The protein is a component of the gastrointestinal tract and pancreatic ducts, acting as an intestinal proton-dependent peptide transporter in the first step in oral absorption of many medically important peptide-based drugs. The protein may also play a role in the morphological organization of liver and intestine.[3]


  1. ^ Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF (Aug 1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235. 
  2. ^ Chalmers IJ, Hofler H, Atkinson MJ (Jun 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID 10191097. 
  3. ^ a b "Entrez Gene: CDH17 cadherin 17, LI cadherin (liver-intestine)". 

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