Cadherin-3, also known as P-Cadherin, is a protein that in humans is encoded by the CDH3gene.
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. This gene is located in a six-cadherin cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. In addition, aberrant expression of this protein is observed in cervical adenocarcinomas. Mutations in this gene have been associated with congential hypotrichosis with juvenile macular dystrophy.
^Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A (December 1992). "The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species". Genomics14 (2): 488–90. doi:10.1016/S0888-7543(05)80247-2. PMID1427864.
^ abcdKlingelhöfer, J; Troyanovsky R B; Laur O Y; Troyanovsky S (August 2000). "Amino-terminal domain of classic cadherins determines the specificity of the adhesive interactions". J. Cell. Sci. (ENGLAND) 113 (16): 2829–36. ISSN0021-9533. PMID10910767.
van der Linden PJ, de Goeij AF, Dunselman GA et al. (1995). "Expression of cadherins and integrins in human endometrium throughout the menstrual cycle.". Fertil. Steril.63 (6): 1210–6. PMID7538474.
Tang A, Eller MS, Hara M et al. (1994). "E-cadherin is the major mediator of human melanocyte adhesion to keratinocytes in vitro.". J. Cell. Sci.107 (4): 983–92. PMID8056851.
Tassin MT, Beziau A, Gubler MC, Boyer B (1994). "Spatiotemporal expression of molecules associated with junctional complexes during the in vivo maturation of renal podocytes.". Int. J. Dev. Biol.38 (1): 45–54. PMID8074995.
Navarro P, Lozano E, Cano A (1993). "Expression of E- or P-cadherin is not sufficient to modify the morphology and the tumorigenic behavior of murine spindle carcinoma cells. Possible involvement of plakoglobin". J. Cell. Sci.105 (4): 923–34. PMID8227214.
Reynolds AB, Daniel JM, Mo YY et al. (1996). "The novel catenin p120cas binds classical cadherins and induces an unusual morphological phenotype in NIH3T3 fibroblasts". Exp. Cell Res.225 (2): 328–37. doi:10.1006/excr.1996.0183. PMID8660921.
Wakita H, Furukawa F, Baba S, Takigawa M (1997). "Human squamous-cell-carcinoma cell line (DJM-1) cells synthesize P-cadherin molecules via an elevation of extracellular calcium: calcium regulates P-cadherin-gene expression at the translational level via protein tyrosine phosphorylation". Int. J. Cancer73 (3): 432–9. doi:10.1002/(SICI)1097-0215(19971104)73:3<432::AID-IJC19>3.0.CO;2-E. PMID9359492.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Kremmidiotis G, Baker E, Crawford J et al. (1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID9615235.
Jarrard DF, Paul R, van Bokhoven A et al. (1999). "P-Cadherin is a basal cell-specific epithelial marker that is not expressed in prostate cancer". Clin. Cancer Res.3 (11): 2121–8. PMID9815605.
Klingelhöfer J, Troyanovsky RB, Laur OY, Troyanovsky S (2000). "Amino-terminal domain of classic cadherins determines the specificity of the adhesive interactions". J. Cell. Sci.113 (16): 2829–36. PMID10910767.