CDH4

From Wikipedia, the free encyclopedia
Jump to: navigation, search
CDH4
Identifiers
Aliases CDH4, CAD4, R-CAD, RCAD, cadherin 4
External IDs MGI: 99218 HomoloGene: 48044 GeneCards: CDH4
Gene location (Human)
Chromosome 20 (human)
Chr. Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for CDH4
Genomic location for CDH4
Band 20q13.33 Start 61,252,426 bp[1]
End 61,940,617 bp[1]
RNA expression pattern
PBB GE CDH4 206866 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001794
NM_001252338
NM_001252339

NM_009867
NM_001316723

RefSeq (protein)

NP_001239267
NP_001239268
NP_001785

NP_001303652
NP_033997

Location (UCSC) Chr 20: 61.25 – 61.94 Mb Chr 20: 179.44 – 179.9 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cadherin-4 is a protein that in humans is encoded by the CDH4 gene.[5][6][7]

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization.[7]

Interactions[edit]

Cadherin-4 has been shown to interact with:

References[edit]

  1. ^ a b c ENSG00000179242 GRCh38: Ensembl release 89: ENSG00000280641, ENSG00000179242 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000305 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Chalmers IJ, Hofler H, Atkinson MJ (Jun 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics. 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID 10191097. 
  6. ^ Kools P, Vanhalst K, van Roy F (Oct 1999). "Assignment of cadherin-4 (R-cadherin, CDH4) to human chromosome band 20q13.3". Cytogenet Cell Genet. 86 (1): 26–7. doi:10.1159/000015423. PMID 10516427. 
  7. ^ a b "Entrez Gene: CDH4 cadherin 4, type 1, R-cadherin (retinal)". 
  8. ^ Brady-Kalnay SM, Mourton T, Nixon JP, Pietz GE, Kinch M, Chen H, et al. (1998). "Dynamic interaction of PTPmu with multiple cadherins in vivo". J Cell Biol. 141 (1): 287–96. doi:10.1083/jcb.141.1.287. PMC 2132733Freely accessible. PMID 9531566. 

Further reading[edit]

External links[edit]