This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization.
^Chalmers IJ, Hofler H, Atkinson MJ (Jun 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics. 57 (1): 160–3. PMID10191097. doi:10.1006/geno.1998.5717.
^Kools P, Vanhalst K, van Roy F (Oct 1999). "Assignment of cadherin-4 (R-cadherin, CDH4) to human chromosome band 20q13.3". Cytogenet Cell Genet. 86 (1): 26–7. PMID10516427. doi:10.1159/000015423.
Tanihara H, Sano K, Heimark RL, et al. (1995). "Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin.". Cell Adhes. Commun. 2 (1): 15–26. PMID7982033. doi:10.3109/15419069409014199.
Kitagawa M, Natori M, Murase S, et al. (2000). "Mutation analysis of cadherin-4 reveals amino acid residues of EC1 important for the structure and function.". Biochem. Biophys. Res. Commun. 271 (2): 358–63. PMID10799302. doi:10.1006/bbrc.2000.2636.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature. 414 (6866): 865–71. PMID11780052. doi:10.1038/414865a.
Miotto E, Sabbioni S, Veronese A, et al. (2005). "Frequent aberrant methylation of the CDH4 gene promoter in human colorectal and gastric cancer.". Cancer Res. 64 (22): 8156–9. PMID15548679. doi:10.1158/0008-5472.CAN-04-3000.
Maeda M, Johnson E, Mandal SH, et al. (2006). "Expression of inappropriate cadherins by epithelial tumor cells promotes endocytosis and degradation of E-cadherin via competition for p120(ctn).". Oncogene. 25 (33): 4595–604. PMID16786001. doi:10.1038/sj.onc.1209396.