CDH4

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CDH4
Identifiers
Aliases CDH4, CAD4, R-CAD, RCAD, cadherin 4
External IDs MGI: 99218 HomoloGene: 48044 GeneCards: 1002
Genetically Related Diseases
Disease Name References
obesity
RNA expression pattern
PBB GE CDH4 206866 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001794
NM_001252338
NM_001252339

NM_009867
NM_001316723

RefSeq (protein)

NP_001239268.1
NP_001785.2

NP_033997.1

Location (UCSC) Chr 20: 61.25 – 61.94 Mb Chr 2: 179.44 – 179.9 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Cadherin-4 is a protein that in humans is encoded by the CDH4 gene.[1][2][3]

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization.[3]

Interactions[edit]

Cadherin-4 has been shown to interact with:

References[edit]

  1. ^ Chalmers IJ, Hofler H, Atkinson MJ (Jun 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID 10191097. 
  2. ^ Kools P, Vanhalst K, van Roy F (Oct 1999). "Assignment of cadherin-4 (R-cadherin, CDH4) to human chromosome band 20q13.3". Cytogenet Cell Genet 86 (1): 26–7. doi:10.1159/000015423. PMID 10516427. 
  3. ^ a b "Entrez Gene: CDH4 cadherin 4, type 1, R-cadherin (retinal)". 
  4. ^ Brady-Kalnay SM, Mourton T, Nixon JP, Pietz GE, Kinch M, Chen H, et al. (1998). "Dynamic interaction of PTPmu with multiple cadherins in vivo.". J Cell Biol 141 (1): 287–96. doi:10.1083/jcb.141.1.287. PMC 2132733. PMID 9531566. 

Further reading[edit]

External links[edit]