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Cadherin 4, type 1, R-cadherin (retinal)
Symbols CDH4 ; CAD4; R-CAD; RCAD
External IDs OMIM603006 MGI99218 HomoloGene48044 GeneCards: CDH4 Gene
RNA expression pattern
PBB GE CDH4 206866 at tn.png
More reference expression data
Species Human Mouse
Entrez 1002 12561
Ensembl ENSG00000179242 ENSMUSG00000000305
UniProt P55283 P39038
RefSeq (mRNA) NM_001252338 NM_009867
RefSeq (protein) NP_001239267 NP_033997
Location (UCSC) Chr 20:
61.25 – 61.94 Mb
Chr 2:
179.44 – 179.9 Mb
PubMed search [1] [2]

Cadherin-4 is a protein that in humans is encoded by the CDH4 gene.[1][2][3]

This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization.[3]


Cadherin-4 has been shown to interact with:


  1. ^ Chalmers IJ, Hofler H, Atkinson MJ (Jun 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID 10191097. 
  2. ^ Kools P, Vanhalst K, van Roy F (Oct 1999). "Assignment of cadherin-4 (R-cadherin, CDH4) to human chromosome band 20q13.3". Cytogenet Cell Genet 86 (1): 26–7. doi:10.1159/000015423. PMID 10516427. 
  3. ^ a b "Entrez Gene: CDH4 cadherin 4, type 1, R-cadherin (retinal)". 
  4. ^ Brady-Kalnay SM, Mourton T, Nixon JP, Pietz GE, Kinch M, Chen H; et al. (1998). "Dynamic interaction of PTPmu with multiple cadherins in vivo.". J Cell Biol 141 (1): 287–96. doi:10.1083/jcb.141.1.287. PMC 2132733. PMID 9531566. 

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