This gene encodes a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell–cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell–cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of this gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion.
^Shimoyama Y, Gotoh M, Terasaki T, Kitajima M, Hirohashi S (June 1995). "Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells". Cancer Res55 (10): 2206–11. PMID7743525.
^Chalmers IJ, Hofler H, Atkinson MJ (June 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID10191097.
MacCalman CD, Getsios S, Chen GT (1998). "Type 2 cadherins in the human endometrium and placenta: their putative roles in human implantation and placentation.". Am. J. Reprod. Immunol.39 (2): 96–107. doi:10.1111/j.1600-0897.1998.tb00341.x. PMID9506208.
Paul R, Ewing CM, Robinson JC, et al. (1997). "Cadherin-6, a cell adhesion molecule specifically expressed in the proximal renal tubule and renal cell carcinoma.". Cancer Res.57 (13): 2741–8. PMID9205085.
Kremmidiotis G, Baker E, Crawford J, et al. (1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity.". Genomics49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID9615235.
Shimoyama Y, Takeda H, Yoshihara S, et al. (1999). "Biochemical characterization and functional analysis of two type II classic cadherins, cadherin-6 and -14, and comparison with E-cadherin.". J. Biol. Chem.274 (17): 11987–94. doi:10.1074/jbc.274.17.11987. PMID10207020.