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Available structures
PDB Ortholog search: PDBe RCSB
Aliases CDH6, CAD6, KCAD, cadherin 6
External IDs MGI: 107435 HomoloGene: 21027 GeneCards: 1004
RNA expression pattern
PBB GE CDH6 205532 s at tn.png

PBB GE CDH6 205533 s at tn.png

PBB GE CDH6 210602 s at tn.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 5: 31.19 – 31.33 Mb Chr 15: 13.03 – 13.17 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Cadherin-6 is a protein that in humans is encoded by the CDH6 gene.[3][4][5]

This gene encodes a type II classical cadherin from the cadherin superfamily. The encoded membrane protein is a calcium dependent cell–cell adhesion glycoprotein composed of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell–cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of this gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion.[5]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Shimoyama Y, Gotoh M, Terasaki T, Kitajima M, Hirohashi S (June 1995). "Isolation and sequence analysis of human cadherin-6 complementary DNA for the full coding sequence and its expression in human carcinoma cells". Cancer Res. 55 (10): 2206–11. PMID 7743525. 
  4. ^ Chalmers IJ, Hofler H, Atkinson MJ (June 1999). "Mapping of a cadherin gene cluster to a region of chromosome 5 subject to frequent allelic loss in carcinoma". Genomics. 57 (1): 160–3. doi:10.1006/geno.1998.5717. PMID 10191097. 
  5. ^ a b "Entrez Gene: CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)". 

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