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Cadherin 8, type 2
Protein CDH8 PDB 1zxk.png
PDB rendering based on 1zxk.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CDH8 ; Nbla04261
External IDs OMIM603008 MGI107434 HomoloGene55604 GeneCards: CDH8 Gene
RNA expression pattern
PBB GE CDH8 210518 at tn.png
More reference expression data
Species Human Mouse
Entrez 1006 12564
Ensembl ENSG00000150394 ENSMUSG00000036510
UniProt P55286 P97291
RefSeq (mRNA) NM_001796 NM_001039154
RefSeq (protein) NP_001787 NP_001034243
Location (UCSC) Chr 16:
61.65 – 62.04 Mb
Chr 8:
99.02 – 99.42 Mb
PubMed search [1] [2]

Cadherin-8 is a protein that in humans is encoded by the CDH8 gene.[1][2][3]

This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is expressed in brain and is putatively involved in synaptic adhesion, axon outgrowth and guidance.[3]


  1. ^ Kremmidiotis G, Baker E, Crawford J, Eyre HJ, Nahmias J, Callen DF (Aug 1998). "Localization of human cadherin genes to chromosome regions exhibiting cancer-related loss of heterozygosity". Genomics 49 (3): 467–71. doi:10.1006/geno.1998.5281. PMID 9615235. 
  2. ^ Suzuki S, Sano K, Tanihara H (Aug 1991). "Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue". Cell Regul 2 (4): 261–70. doi:10.1091/mbc.2.4.261. PMC 361775. PMID 2059658. 
  3. ^ a b "Entrez Gene: CDH8 cadherin 8, type 2". 

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