CDK2AP1

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CDK2AP1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CDK2AP1, DOC1, DORC1, ST19, doc-1, p12DOC-1, cyclin-dependent kinase 2 associated protein 1, cyclin dependent kinase 2 associated protein 1
External IDs MGI: 1202069 HomoloGene: 3411 GeneCards: CDK2AP1
RNA expression pattern
PBB GE CDK2AP1 201938 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001270433
NM_001270434
NM_004642

NM_013812

RefSeq (protein)

NP_001257362
NP_001257363
NP_004633

NP_038840.2
NP_038840

Location (UCSC) Chr 12: 123.26 – 123.27 Mb Chr 5: 124.35 – 124.36 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cyclin-dependent kinase 2-associated protein 1 is an enzyme that in humans is encoded by the CDK2AP1 gene.[3][4][5]

Function[edit]

The protein encoded by this gene is a specific CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggested the regulatory role in DNA replication during S phase of the cell cycle. A similar gene in hamster was isolated from, and functions as a growth suppressor of normal keratinocytes.[5]

Interactions[edit]

CDK2AP1 has been shown to interact with Cyclin-dependent kinase 2.[6]

It interacts with unnamed protein product (BC006130) which may mediate inhibitory effect of CDK2AP1 on cell proliferation.[7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Daigo Y, Suzuki K, Maruyama O, Miyoshi Y, Yasuda T, Kabuto T, Imaoka S, Fujiwara T, Takahashi E, Fujino MA, Nakamura Y (November 1997). "Isolation, mapping and mutation analysis of a human cDNA homologous to the doc-1 gene of the Chinese hamster, a candidate tumor suppressor for oral cancer". Genes Chromosomes Cancer. 20 (2): 204–7. doi:10.1002/(SICI)1098-2264(199710)20:2<204::AID-GCC12>3.0.CO;2-Q. PMID 9331572. 
  4. ^ Tsuji T, Duh FM, Latif F, Popescu NC, Zimonjic DB, McBride J, Matsuo K, Ohyama H, Todd R, Nagata E, Terakado N, Sasaki A, Matsumura T, Lerman MI, Wong DT (April 1998). "Cloning, mapping, expression, function, and mutation analyses of the human ortholog of the hamster putative tumor suppressor gene Doc-1". J Biol Chem. 273 (12): 6704–9. doi:10.1074/jbc.273.12.6704. PMID 9506968. 
  5. ^ a b "Entrez Gene: CDK2AP1 CDK2-associated protein 1". 
  6. ^ Shintani S, Ohyama H, Zhang X, McBride J, Matsuo K, Tsuji T, Hu MG, Hu G, Kohno Y, Lerman M, Todd R, Wong DT (September 2000). "p12DOC-1 Is a Novel Cyclin-Dependent Kinase 2-Associated Protein". Mol. Cell. Biol. 20 (17): 6300–7. doi:10.1128/MCB.20.17.6300-6307.2000. PMC 86104Freely accessible. PMID 10938106. 
  7. ^ Liu L, Yang X, Ni Q, Xiao Z, Zhao Y, Han J, Sun M, Chen B (Jan 2014). "Interaction between p12CDK2AP1 and a novel unnamed protein product inhibits cell proliferation by regulating the cell cycle.". J Mol Med Rep. 9 (1): 156–62. doi:10.3892/mmr.2013.1801. PMID 24248101. 

External links[edit]

Further reading[edit]