CDK5R2

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CDK5R2
Identifiers
AliasesCDK5R2, NCK5AI, P39, p39nck5ai, cyclin-dependent kinase 5, regulatory subunit 2 (p39), cyclin dependent kinase 5 regulatory subunit 2
External IDsMGI: 1330828 HomoloGene: 2924 GeneCards: CDK5R2
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for CDK5R2
Genomic location for CDK5R2
Band2q35Start218,959,655 bp[1]
End218,962,162 bp[1]
RNA expression pattern
PBB GE CDK5R2 205852 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003936

NM_009872

RefSeq (protein)

NP_003927

NP_034002

Location (UCSC)Chr 2: 218.96 – 218.96 MbChr 1: 74.85 – 74.86 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cyclin-dependent kinase 5 activator 2 is an enzyme that in humans is encoded by the CDK5R2 gene.[5][6]

The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. It associates with CDK5 to form an active kinase. This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins.[6]

Interactions[edit]

CDK5R2 has been shown to interact with Actinin, alpha 1.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000171450 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000090071 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Tang D, Yeung J, Lee KY, Matsushita M, Matsui H, Tomizawa K, Hatase O, Wang JH (Dec 1995). "An isoform of the neuronal cyclin-dependent kinase 5 (Cdk5) activator". J Biol Chem. 270 (45): 26897–903. doi:10.1074/jbc.270.45.26897. PMID 7592934. 
  6. ^ a b "Entrez Gene: CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39)". 
  7. ^ Dhavan, Rani; Greer Paul L; Morabito Maria A; Orlando Lianna R; Tsai Li-Huei (Sep 2002). "The cyclin-dependent kinase 5 activators p35 and p39 interact with the alpha-subunit of Ca2+/calmodulin-dependent protein kinase II and alpha-actinin-1 in a calcium-dependent manner". J. Neurosci. United States. 22 (18): 7879–91. PMID 12223541. 

External links[edit]

Further reading[edit]