CDKN2BAS

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CDKN2B-AS1
Identifiers
Aliases CDKN2B-AS1, ANRIL, CDKN2B-AS, CDKN2BAS, NCRNA00089, PCAT12, p15AS, CDKN2B-AS1, CDKN2B antisense RNA 1
External IDs GeneCards: CDKN2B-AS1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC) Chr 9: 21.99 – 22.12 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human
CDKN2B antisense RNA 1 intronic convserved region
CDKN2B-AS secondary structure.jpg
Predicted secondary structure and sequence conservation of CDKN2B-AS
Identifiers
Symbol CDKN2B-AS
Alt. Symbols ANRIL
Rfam RF01909
Other data
RNA type Gene;
Domain(s) Eukaryota;
GO 0006342 0005515
SO 0001463

CDKN2B-AS, also known as ANRIL (antisense non-coding RNA in the INK4 locus) is a long non-coding RNA consisting of 19 exons, spanning 126.3kb in the genome, and its spliced product is a 3834bp RNA. It is located within the p15/CDKN2B-p16/CDKN2A-p14/ARF gene cluster, in the antisense direction. Single nucleotide polymorphisms (SNPs) which alter the expression of CDKN2B-AS are associated with many diseases, including coronary artery disease, diabetes and many cancers.[2] It binds to chromobox 7 (CBX7) within the polycomb repressive complex 1 and to SUZ12, a component of polycomb repression complex 2 and through these interactions is involved in transcriptional repression.[3][4]

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