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CE-123 Structure.svg
Legal status
Legal status
  • (S)-5-(benzhydrylsulfinylmethyl)-1,3-thiazole
CAS Number
PubChem CID
Chemical and physical data
Molar mass329.43 g·mol−1
3D model (JSmol)
  • O=S(Cc1cncs1)C(c2ccccc2)c3ccccc3
  • InChI=1S/C17H15NOS2/c19-21(12-16-11-18-13-20-16)17(14-7-3-1-4-8-14)15-9-5-2-6-10-15/h1-11,13,17H,12H2

CE-123 is an analog of modafinil, the most researched of a series of structurally related heterocyclic derivatives.[1][2][3] In animal studies, CE-123 was found to improve performance on tests of learning and memory in a manner consistent with a nootropic effect profile.[4][5][6][7]

See also[edit]


  1. ^ Sase A, Aher YD, Saroja SR, Ganesan MK, Sase S, Holy M, et al. (March 2016). "A heterocyclic compound CE-103 inhibits dopamine reuptake and modulates dopamine transporter and dopamine D1-D3 containing receptor complexes". Neuropharmacology. 102: 186–96. doi:10.1016/j.neuropharm.2015.07.039. PMID 26407764. S2CID 19840397.
  2. ^ Saroja SR, Aher YD, Kalaba P, Aher NY, Zehl M, Korz V, et al. (October 2016). "A novel heterocyclic compound targeting the dopamine transporter improves performance in the radial arm maze and modulates dopamine receptors D1-D3". Behavioural Brain Research. 312: 127–37. doi:10.1016/j.bbr.2016.06.011. PMID 27288589. S2CID 38509577.
  3. ^ Hussein AM, Aher YD, Kalaba P, Aher NY, Dragačević V, Radoman B, et al. (August 2017). "A novel heterocyclic compound improves working memory in the radial arm maze and modulates the dopamine receptor D1R in frontal cortex of the Sprague-Dawley rat". Behavioural Brain Research. 332: 308–315. doi:10.1016/j.bbr.2017.06.023. PMID 28629964. S2CID 205895268.
  4. ^ Nikiforuk A, Kalaba P, Ilic M, Korz V, Dragačević V, Wackerlig J, et al. (2017). "A Novel Dopamine Transporter Inhibitor CE-123 Improves Cognitive Flexibility and Maintains Impulsivity in Healthy Male Rats". Frontiers in Behavioral Neuroscience. 11: 222. doi:10.3389/fnbeh.2017.00222. PMC 5711856. PMID 29230168.
  5. ^ Kristofova M, Aher YD, Ilic M, Radoman B, Kalaba P, Dragacevic V, et al. (May 2018). "A daily single dose of a novel modafinil analogue CE-123 improves memory acquisition and memory retrieval". Behavioural Brain Research. 343: 83–94. doi:10.1016/j.bbr.2018.01.032. PMID 29410048. S2CID 3551334.
  6. ^ Camats-Perna J, Kalaba P, Ebner K, Sartori SB, Vuyyuru H, Aher NY, et al. (2019). "Differential Effects of Novel Dopamine Reuptake Inhibitors on Interference With Long-Term Social Memory in Mice". Frontiers in Behavioral Neuroscience. 13: 63. doi:10.3389/fnbeh.2019.00063. PMC 6470289. PMID 31031603.
  7. ^ Rotolo RA, Dragacevic V, Kalaba P, Urban E, Zehl M, Roller A, et al. (2019). "(S)-CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and Increases Progressive Ratio Responding". Frontiers in Pharmacology. 10: 682. doi:10.3389/fphar.2019.00682. PMC 6611521. PMID 31316379.