CELA2A

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CELA2A
Identifiers
Aliases CELA2A, ELA2A, PE-1, chymotrypsin like elastase family member 2A
External IDs MGI: 95316 HomoloGene: 40598 GeneCards: CELA2A
RNA expression pattern
PBB GE PNPLA6 203718 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_033440

NM_007919

RefSeq (protein)

NP_254275

NP_031945.1
NP_031945

Location (UCSC) Chr 1: 15.46 – 15.47 Mb Chr 4: 141.81 – 141.83 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Chymotrypsin-like elastase family member 2A is an enzyme that in humans is encoded by the CELA2A gene.[3][4][5]

Function[edit]

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. Clinical literature that describes human elastase 1 activity in the pancreas is actually referring to elastase 2A.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Kawashima I, Tani T, Shimoda K, Takiguchi Y (Jul 1987). "Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas". DNA. 6 (2): 163–72. doi:10.1089/dna.1987.6.163. PMID 3646943. 
  4. ^ Shirasu Y, Yoshida H, Matsuki S, Takemura K, Ikeda N, Shimada Y, Ozawa T, Mikayama T, Iijima H, Ishida A, et al. (Jun 1988). "Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2". J Biochem. 102 (6): 1555–63. PMID 2834346. 
  5. ^ a b "Entrez Gene: ELA2A elastase 2A". 

External links[edit]

Further reading[edit]