CELSR1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
CELSR1
Identifiers
Aliases CELSR1, CDHF9, FMI2, HFMI2, ME2, ADGRC1, cadherin EGF LAG seven-pass G-type receptor 1
External IDs MGI: 1100883 HomoloGene: 7665 GeneCards: 9620
RNA expression pattern
PBB GE CELSR1 204539 s at tn.png

PBB GE CELSR1 217262 s at tn.png

PBB GE CELSR1 41660 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014246

NM_009886

RefSeq (protein)

NP_055061.1

NP_034016.2

Location (UCSC) Chr 22: 46.36 – 46.54 Mb Chr 15: 85.9 – 86.03 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cadherin EGF LAG seven-pass G-type receptor 1 also known as flamingo homolog 2 or cadherin family member 9 is a protein that in humans is encoded by the CELSR1 gene.[3][4]

Function[edit]

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin G-like domains in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis.[4]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Hadjantonakis AK, Sheward WJ, Harmar AJ, de Galan L, Hoovers JM, Little PF (Nov 1997). "Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter". Genomics. 45 (1): 97–104. doi:10.1006/geno.1997.4892. PMID 9339365. 
  4. ^ a b "Entrez Gene: CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)". 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.