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Available structures
PDB Ortholog search: PDBe RCSB
Aliases CENPM, C22orf18, CENP-M, PANE1, bK250D10.2, centromere protein M
External IDs MGI: 1913820 HomoloGene: 11438 GeneCards: CENPM
Gene location (Human)
Chromosome 22 (human)
Chr. Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for CENPM
Genomic location for CENPM
Band 22q13.2 Start 41,938,721 bp[1]
End 41,947,164 bp[1]
RNA expression pattern
PBB GE CENPM 218741 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)


RefSeq (protein)


Location (UCSC) Chr 22: 41.94 – 41.95 Mb Chr 15: 82.23 – 82.24 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Centromere protein M also known as proliferation associated nuclear element 1 (PANE1) is a protein that in humans is encoded by the CENPM gene.[5][6][7]

An alternative transcript of the CENPM gene encodes a leukocyte antigen that is selectively expressed in B-lymphoid cells.[8][9] Centromere protein M us involved in centromere assembly and immune response.[10]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100162 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000068101 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nature Cell Biology. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420. 
  6. ^ Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nature Cell Biology. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419. 
  7. ^ "Entrez Gene: CENPM centromere protein M". 
  8. ^ Brickner AG, Evans AM, Mito JK, Xuereb SM, Feng X, Nishida T, Fairfull L, Ferrell RE, Foon KA, Hunt DF, Shabanowitz J, Engelhard VH, Riddell SR, Warren EH (2006). "The PANE1 gene encodes a novel human minor histocompatibility antigen that is selectively expressed in B-lymphoid cells and B-CLL". Blood. 107 (9): 3779–86. doi:10.1182/blood-2005-08-3501. PMC 1895781Freely accessible. PMID 16391015. 
  9. ^ Bierie B, Edwin M, Melenhorst JJ, Hennighausen L (July 2004). "The proliferation associated nuclear element (PANE1) is conserved between mammals and fish and preferentially expressed in activated lymphoid cells". Gene Expression Patterns. 4 (4): 389–95. doi:10.1016/j.modgep.2004.01.008. PMID 15183305. 
  10. ^ Huang H, Deng H, Yang Y, Tang Z, Yang S, Mu Y, Cui W, Yuan J, Wu Z, Li K (2010). "Molecular characterization and association analysis of porcine PANE1 gene". Molecular Biology Reports. 37 (5): 2571–7. doi:10.1007/s11033-009-9775-0. PMID 19711193. 

Further reading[edit]

  • Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (February 2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes to Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. 
  • Izuta H, Ikeno M, Suzuki N, Tomonaga T, Nozaki N, Obuse C, Kisu Y, Goshima N, Nomura F, Nomura N, Yoda K (June 2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes to Cells. 11 (6): 673–84. doi:10.1111/j.1365-2443.2006.00969.x. PMID 16716197. 

External links[edit]