CENPO

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CENPO
Identifiers
Aliases CENPO, CENP-O, ICEN-36, MCM21R, centromere protein O
External IDs MGI: 1923800 HomoloGene: 49760 GeneCards: CENPO
RNA expression pattern
PBB GE CENPO 219472 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001199803
NM_024322
NM_001322101

NM_134046

RefSeq (protein)

NP_001186732
NP_001309030
NP_077298

NP_598807.2
NP_598807

Location (UCSC) Chr 2: 24.79 – 24.82 Mb Chr 12: 4.2 – 4.23 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Centromere protein O is a protein that in humans is encoded by the CENPO gene.[3][4][5] CENPO is involved in cell proliferation and cell cycle progression and has been shown to be down-regulated in trisomic neurospheres a mouse model of Down Syndrome, resulting in reduced numbers of neural progenitors and neuroblasts and a severe reduction in numbers of neurons produced. [6]


References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR 3rd, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nat Cell Biol. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420. 
  4. ^ Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR 3rd, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nat Cell Biol. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419. 
  5. ^ "Entrez Gene: CENPO centromere protein O". 
  6. ^ Hewitt, Chelsee A.; Ling, King-Hwa; Merson, Tobias D.; Simpson, Ken M.; Ritchie, Matthew E.; King, Sarah L.; Pritchard, Melanie A.; Smyth, Gordon K.; Thomas, Tim (2010-07-16). "Gene Network Disruptions and Neurogenesis Defects in the Adult Ts1Cje Mouse Model of Down Syndrome". PLOS ONE. 5 (7): e11561. doi:10.1371/journal.pone.0011561. ISSN 1932-6203. PMC 2905390Freely accessible. PMID 20661276. 

External links[edit]

Further reading[edit]