CENTD3

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ARAP3
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ARAP3, CENTD3, DRAG1, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
External IDs MGI: 2147274 HomoloGene: 11199 GeneCards: ARAP3
RNA expression pattern
PBB GE CENTD3 gnf1h07750 at fs.png

PBB GE CENTD3 gnf1h01471 at fs.png

PBB GE CENTD3 218950 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_022481

NM_001205336
NM_139206

RefSeq (protein)

NP_071926

NP_001192265.1
NP_631945.2
NP_001192265
NP_631945

Location (UCSC) Chr 5: 141.65 – 141.68 Mb Chr 18: 37.97 – 38 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 is a protein that in humans is encoded by the ARAP3 gene.[3][4][5]

This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its full-length nature has not been determined.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Krugmann S, Anderson KE, Ridley SH, Risso N, McGregor A, Coadwell J, Davidson K, Eguinoa A, Ellson CD, Lipp P, Manifava M, Ktistakis N, Painter G, Thuring JW, Cooper MA, Lim ZY, Holmes AB, Dove SK, Michell RH, Grewal A, Nazarian A, Erdjument-Bromage H, Tempst P, Stephens LR, Hawkins PT (Jan 2002). "Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices". Mol Cell. 9 (1): 95–108. doi:10.1016/S1097-2765(02)00434-3. PMID 11804589. 
  4. ^ Santy LC, Casanova JE (May 2002). "GTPase signaling: bridging the GAP between ARF and Rho". Curr Biol. 12 (10): R360–2. doi:10.1016/S0960-9822(02)00860-6. PMID 12015138. 
  5. ^ a b "Entrez Gene: CENTD3 centaurin, delta 3". 

External links[edit]

Further reading[edit]