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Centrosomal protein 164kDa
Symbols CEP164 ; NPHP15
External IDs OMIM614848 MGI2384878 HomoloGene51110 GeneCards: CEP164 Gene
Species Human Mouse
Entrez 22897 214552
Ensembl ENSG00000110274 ENSMUSG00000043987
UniProt Q9UPV0 Q5DU05
RefSeq (mRNA) NM_001271933 NM_001081373
RefSeq (protein) NP_001258862 NP_001074842
Location (UCSC) Chr 11:
117.19 – 117.28 Mb
Chr 9:
45.77 – 45.83 Mb
PubMed search [1] [2]

Centrosomal protein of 164 kDa, also known as CEP164, is a protein that in humans is encoded by the CEP164 gene.[1][2] Its function appears two be twofold: CEP164 is required for primary cilium formation.[3] Furthermore, it is an important component in the response to DNA damage by UV light.[4][5]


  1. ^ "Entrez Gene: centrosomal protein 164kDa". 
  2. ^ Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (December 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843. 
  3. ^ Graser, S.; Stierhof, Y. -D.; Lavoie, S. B.; Gassner, O. S.; Lamla, S.; Le Clech, M.; Nigg, E. A. (2007). "Cep164, a novel centriole appendage protein required for primary cilium formation". The Journal of Cell Biology 179 (2): 321–30. doi:10.1083/jcb.200707181. PMC 2064767. PMID 17954613.  edit
  4. ^ Sivasubramaniam, S.; Sun, X.; Pan, Y. -R.; Wang, S.; Lee, E. Y. -H. P. (2008). "Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1". Genes & Development 22 (5): 587–600. doi:10.1101/gad.1627708. PMC 2259029. PMID 18283122.  edit
  5. ^ Pan, YR; Lee, EY (2009). "UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity". Cell cycle (Georgetown, Tex.) 8 (4): 655–64. doi:10.4161/cc.8.4.7844. PMID 19197159.  edit

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