CEP164

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CEP164
Identifiers
Aliases CEP164, NPHP15, centrosomal protein 164
External IDs MGI: 2384878 HomoloGene: 51110 GeneCards: CEP164
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001271933
NM_014956

NM_001081373
NM_172531

RefSeq (protein)

NP_001258862
NP_055771

n/a

Location (UCSC) Chr 11: 117.31 – 117.41 Mb Chr 9: 45.77 – 45.83 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Centrosomal protein of 164 kDa, also known as CEP164, is a protein that in humans is encoded by the CEP164 gene.[3][4] Its function appears two be twofold: CEP164 is required for primary cilium formation.[5] Furthermore, it is an important component in the response to DNA damage by UV light.[6][7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ "Entrez Gene: centrosomal protein 164kDa". 
  4. ^ Andersen JS, Wilkinson CJ, Mayor T, Mortensen P, Nigg EA, Mann M (December 2003). "Proteomic characterization of the human centrosome by protein correlation profiling". Nature. 426 (6966): 570–4. doi:10.1038/nature02166. PMID 14654843. 
  5. ^ Graser, S.; Stierhof, Y. -D.; Lavoie, S. B.; Gassner, O. S.; Lamla, S.; Le Clech, M.; Nigg, E. A. (2007). "Cep164, a novel centriole appendage protein required for primary cilium formation". The Journal of Cell Biology. 179 (2): 321–30. doi:10.1083/jcb.200707181. PMC 2064767Freely accessible. PMID 17954613. 
  6. ^ Sivasubramaniam, S.; Sun, X.; Pan, Y. -R.; Wang, S.; Lee, E. Y. -H. P. (2008). "Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1". Genes & Development. 22 (5): 587–600. doi:10.1101/gad.1627708. PMC 2259029Freely accessible. PMID 18283122. 
  7. ^ Pan, YR; Lee, EY (2009). "UV-dependent interaction between Cep164 and XPA mediates localization of Cep164 at sites of DNA damage and UV sensitivity". Cell cycle (Georgetown, Tex.). 8 (4): 655–64. doi:10.4161/cc.8.4.7844. PMID 19197159. 

External links[edit]

Further reading[edit]