CEP170

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CEP170
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CEP170, FAM68A, KAB, KIAA0470, centrosomal protein 170
External IDs MGI: 1918348 HomoloGene: 22844 GeneCards: CEP170
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001042404
NM_001042405
NM_014812

NM_001024722
NM_001099637

RefSeq (protein)

NP_001035863
NP_001035864
NP_055627

NP_001093107

Location (UCSC) Chr 1: 243.12 – 243.26 Mb Chr 1: 176.73 – 176.81 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Centrosomal protein 170kDa, also known as CEP170, is a protein that in humans is encoded by the CEP170 gene.[3][4]

Function[edit]

The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with the intraflagellar transport protein 81 (IFT81), the SH3-domain containing protein PRAX-1, and is phosphorylated by cyclin dependent kinase 1 ( Cdk1 ) and polo-like kinase 1 ( PLK1 ), and functions in maintaining Microtubule organization, cell morphology and cilium stability.[3]

The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined.[3]

References[edit]

External links[edit]

Further reading[edit]