CEP250

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CEP250
Identifiers
Aliases CEP250, C-NAP1, CEP2, CNAP1, centrosomal protein 250
External IDs MGI: 108084 HomoloGene: 38286 GeneCards: CEP250
RNA expression pattern
PBB GE CEP250 210894 s at fs.png

PBB GE CEP250 209495 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001035518
NM_007186
NM_001318219

NM_001129999
NM_001130000
NM_008383
NM_177217

RefSeq (protein)

NP_001305148
NP_009117

Location (UCSC) Chr 20: 35.46 – 35.52 Mb Chr 2: 155.96 – 156 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Centrosome-associated protein CEP250 is a protein that in humans is encoded by the CEP250 gene.[3][4][5] This gene encodes a core centrosomal protein required for centriole-centriole cohesion during interphase of the cell cycle. The encoded protein dissociates from the centrosomes when parental centrioles separate at the beginning of mitosis. The protein associates with and is phosphorylated by NIMA-related kinase 2, which is also associated with the centrosome.[5] Furthermore, CEP135 is also required for the centriolar localization of CEP250.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Mack GJ, Rees J, Sandblom O, Balczon R, Fritzler MJ, Rattner JB (Apr 1998). "Autoantibodies to a group of centrosomal proteins in human autoimmune sera reactive with the centrosome". Arthritis Rheum. 41 (3): 551–8. doi:10.1002/1529-0131(199803)41:3<551::AID-ART22>3.0.CO;2-X. PMID 9506584. 
  4. ^ Fry AM, Mayor T, Meraldi P, Stierhof YD, Tanaka K, Nigg EA (Aug 1998). "C-Nap1, a Novel Centrosomal Coiled-Coil Protein and Candidate Substrate of the Cell Cycle–regulated Protein Kinase Nek2". J Cell Biol. 141 (7): 1563–74. doi:10.1083/jcb.141.7.1563. PMC 2133000Freely accessible. PMID 9647649. 
  5. ^ a b "Entrez Gene: CEP250 centrosomal protein 250kDa". 
  6. ^ Kim K, Lee S, Chang J, Rhee K (December 2008). "A novel function of CEP135 as a platform protein of C-NAP1 for its centriolar localization". Exp. Cell Res. 314 (20): 3692–700. doi:10.1016/j.yexcr.2008.09.016. PMID 18851962. 

External links[edit]

Further reading[edit]