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Protein CEP350 PDB 2coz.png
Available structures
PDB Human UniProt search: PDBe RCSB
Aliases CEP350, CAP350, GM133, centrosomal protein 350
External IDs MGI: 1921331 HomoloGene: 8879 GeneCards: CEP350
RNA expression pattern
PBB GE CEP350 213165 at fs.png

PBB GE CEP350 213956 at fs.png

PBB GE CEP350 204373 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 1: 179.95 – 180.11 Mb Chr 1: 155.84 – 155.97 Mb
PubMed search [1] [2]
View/Edit Human View/Edit Mouse

Centrosome-associated protein 350 is a protein that in humans is encoded by the CEP350 gene.[3][4][5]

CEP350 is a large protein with a CAP-Gly domain typically found in cytoskeleton-associated proteins. It primarily localizes to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. CEP350 is required to anchor microtubules at the centrosome. Furthermore, it increases the stability of growing centrioles.[6]

It is also implicated in the regulation of a class of nuclear hormone receptors in the nucleus. Several alternatively spliced transcript variants have been found, but their full-length nature has not been determined.[5]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Yan X, Habedanck R, Nigg EA (Jan 2006). "A Complex of Two Centrosomal Proteins, CAP350 and FOP, Cooperates with EB1 in Microtubule Anchoring". Mol Biol Cell. 17 (2): 634–44. doi:10.1091/mbc.E05-08-0810. PMC 1356575Freely accessible. PMID 16314388. 
  4. ^ Patel H, Truant R, Rachubinski RA, Capone JP (Dec 2004). "Activity and subcellular compartmentalization of peroxisome proliferator-activated receptor alpha are altered by the centrosome-associated protein CAP350". J Cell Sci. 118 (Pt 1): 175–86. doi:10.1242/jcs.01600. PMID 15615782. 
  5. ^ a b "Entrez Gene: CEP350 centrosomal protein 350kDa". 
  6. ^ Le Clech, M (2008). "Role of CAP350 in centriolar tubule stability and centriole assembly.". PLoS ONE. 3 (12): e3855. doi:10.1371/journal.pone.0003855. PMC 2586089Freely accessible. PMID 19052644. 

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