Centrin 2

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CETN2
Protein CETN2 PDB 1m39.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CETN2, CALT, CEN2, centrin 2
External IDs MGI: 1347085 HomoloGene: 55798 GeneCards: CETN2
RNA expression pattern
PBB GE CETN2 209194 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004344

NM_019405

RefSeq (protein)

NP_004335

NP_062278.2
NP_062278

Location (UCSC) Chr X: 152.83 – 152.83 Mb Chr X: 72.91 – 72.92 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Centrin-2 is a protein that in humans is encoded by the CETN2 gene.[3][4][5] It belongs to the centrin family of proteins.

Caltractin belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that caltractin plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome.[5]

Interactions[edit]

CETN2 has been shown to interact with XPC[6] and SFI1.[7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Tanaka T, Okui K, Nakamura Y (May 1995). "Assignment of the human caltractin gene (CALT) to Xq28 by fluorescence in situ hybridization". Genomics. 24 (3): 609–10. PMID 7713520. 
  4. ^ Chatterjee A, Tanaka T, Parrish JE, Herman GE (Apr 1996). "Refined mapping of caltractin in human Xq28 and in the homologous region of the mouse X chromosome places the gene within the bare patches (Bpa) and striated (Str) critical regions". Mamm Genome. 6 (11): 802–4. doi:10.1007/BF00539008. PMID 8597638. 
  5. ^ a b "Entrez Gene: CETN2 centrin, EF-hand protein, 2". 
  6. ^ Araki, M; Masutani C; Takemura M; Uchida A; Sugasawa K; Kondoh J; Ohkuma Y; Hanaoka F (Jun 2001). "Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair". J. Biol. Chem. United States. 276 (22): 18665–72. doi:10.1074/jbc.M100855200. ISSN 0021-9258. PMID 11279143. 
  7. ^ Martinez-Sanz, J; Kateb, F; Assairi, L; Blouquit, Y; Bodenhausen, G; Abergel, D; Mouawad, L; Craescu, CT (Jan 8, 2010). "Structure, dynamics and thermodynamics of the human centrin 2/hSfi1 complex.". Journal of Molecular Biology. 395 (1): 191–204. doi:10.1016/j.jmb.2009.10.041. PMID 19857500. 

External links[edit]

Further reading[edit]