Centrin 2

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Protein CETN2 PDB 1m39.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases CETN2, CALT, CEN2, centrin 2
External IDs MGI: 1347085 HomoloGene: 55798 GeneCards: CETN2
Gene location (Human)
X chromosome (human)
Chr. X chromosome (human)[1]
X chromosome (human)
Genomic location for CETN2
Genomic location for CETN2
Band Xq28 Start 152,826,973 bp[1]
End 152,830,777 bp[1]
RNA expression pattern
PBB GE CETN2 209194 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr X: 152.83 – 152.83 Mb Chr X: 72.91 – 72.92 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Centrin-2 is a protein that in humans is encoded by the CETN2 gene.[5][6][7] It belongs to the centrin family of proteins.

Caltractin belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that caltractin plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome.[7]


CETN2 has been shown to interact with XPC[8] and SFI1.[9]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000147400 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031347 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Tanaka T, Okui K, Nakamura Y (May 1995). "Assignment of the human caltractin gene (CALT) to Xq28 by fluorescence in situ hybridization". Genomics. 24 (3): 609–10. PMID 7713520. 
  6. ^ Chatterjee A, Tanaka T, Parrish JE, Herman GE (Apr 1996). "Refined mapping of caltractin in human Xq28 and in the homologous region of the mouse X chromosome places the gene within the bare patches (Bpa) and striated (Str) critical regions". Mamm Genome. 6 (11): 802–4. doi:10.1007/BF00539008. PMID 8597638. 
  7. ^ a b "Entrez Gene: CETN2 centrin, EF-hand protein, 2". 
  8. ^ Araki, M; Masutani C; Takemura M; Uchida A; Sugasawa K; Kondoh J; Ohkuma Y; Hanaoka F (Jun 2001). "Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair". J. Biol. Chem. United States. 276 (22): 18665–72. doi:10.1074/jbc.M100855200. ISSN 0021-9258. PMID 11279143. 
  9. ^ Martinez-Sanz, J; Kateb, F; Assairi, L; Blouquit, Y; Bodenhausen, G; Abergel, D; Mouawad, L; Craescu, CT (Jan 8, 2010). "Structure, dynamics and thermodynamics of the human centrin 2/hSfi1 complex". Journal of Molecular Biology. 395 (1): 191–204. doi:10.1016/j.jmb.2009.10.041. PMID 19857500. 

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