Centrin 3

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CETN3
Identifiers
AliasesCETN3, CDC31, CEN3, centrin 3
External IDsOMIM: 602907 MGI: 1097706 HomoloGene: 74521 GeneCards: CETN3
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for CETN3
Genomic location for CETN3
Band5q14.3Start90,392,261 bp[1]
End90,409,786 bp[1]
RNA expression pattern
PBB GE CETN3 209662 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004365
NM_001297765
NM_001297768

NM_007684

RefSeq (protein)

NP_001284694
NP_001284697
NP_004356

NP_031710

Location (UCSC)Chr 5: 90.39 – 90.41 MbChr 13: 81.78 – 81.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centrin-3 is a protein that in humans is encoded by the CETN3 gene.[5][6] It belongs to the centrin family of proteins.

The protein encoded by this gene contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Centrins are evolutionarily conserved proteins similar to the CDC31 protein of S. cerevisiae. Yeast CDC31 is located at the centrosome of interphase and mitotic cells, where it plays a fundamental role in centrosome duplication and separation. Multiple forms of the proteins similar to the yeast centrin have been identified in human and other mammalian cells, some of which have been shown to be associated with centrosome fractions. This protein appears to be one of the most abundant centrins associated with centrosome, which suggests a similar function to its yeast counterpart.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000153140 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021537 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Middendorp S, Paoletti A, Schiebel E, Bornens M (Sep 1997). "Identification of a new mammalian centrin gene, more closely related to Saccharomyces cerevisiae CDC31 gene". Proc Natl Acad Sci U S A. 94 (17): 9141–6. doi:10.1073/pnas.94.17.9141. PMC 23077. PMID 9256449.
  6. ^ a b "Entrez Gene: CETN3 centrin, EF-hand protein, 3 (CDC31 homolog, yeast)".

External links[edit]

Further reading[edit]