CFLAR

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CFLAR
Protein CFLAR PDB 3H11.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, CASP8 and FADD like apoptosis regulator
External IDs MGI: 1336166 HomoloGene: 7652 GeneCards: CFLAR
RNA expression pattern
PBB GE CFLAR 211317 s at fs.png

PBB GE CFLAR 208485 x at fs.png

PBB GE CFLAR 209508 x at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001289704
NM_001293804
NM_001293805
NM_009805
NM_207653

RefSeq (protein)
Location (UCSC) Chr 2: 201.12 – 201.18 Mb Chr 1: 58.71 – 58.76 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene.[3][4] Also called c-FLIP (FLICE-like inhibitory protein).


References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Shu HB, Halpin DR, Goeddel DV (Jul 1997). "Casper is a FADD- and caspase-related inducer of apoptosis". Immunity. 6 (6): 751–63. doi:10.1016/S1074-7613(00)80450-1. PMID 9208847. 
  4. ^ Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schroter M, Burns K, Mattmann C, Rimoldi D, French LE, Tschopp J (Jul 1997). "Inhibition of death receptor signals by cellular FLIP". Nature. 388 (6638): 190–5. doi:10.1038/40657. PMID 9217161. 

External links[edit]

Further reading[edit]

  • Abe K, Kurakin A, Mohseni-Maybodi M, et al. (2001). "The complexity of TNF-related apoptosis-inducing ligand.". Ann. N. Y. Acad. Sci. 926 (1): 52–63. doi:10.1111/j.1749-6632.2000.tb05598.x. PMID 11193041. 
  • Dutton A, Young LS, Murray PG (2006). "The role of cellular FLICE inhibitory protein (c-FLIP) in the pathogenesis and treatment of cancer.". Expert Opin. Ther. Targets. 10 (1): 27–35. doi:10.1517/14728222.10.1.27. PMID 16441226.