CGB2 (gene)

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Protein CGB2 PDB 1hcn.png
Aliases CGB2, chorionic gonadotropin beta subunit 2
External IDs HomoloGene: 137643 GeneCards: CGB2
RNA expression pattern
PBB GE CGB1 205387 s at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 19: 49.03 – 49.03 Mb n/a
PubMed search [1] n/a
View/Edit Human

Choriogonadotropin subunit beta variant 2 is a protein that in humans is encoded by the CGB2 gene.[2][3]

The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB2 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits PMID 8954017. However, a 163 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits.[3]


  1. ^ "Human PubMed Reference:". 
  2. ^ Policastro P, Ovitt CE, Hoshina M, Fukuoka H, Boothby MR, Boime I (Nov 1983). "The beta subunit of human chorionic gonadotropin is encoded by multiple genes". J Biol Chem. 258 (19): 11492–9. PMID 6194155. 
  3. ^ a b "Entrez Gene: CGB2 chorionic gonadotropin, beta polypeptide 2". 

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