CHD1L

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CHD1L
Identifiers
Aliases CHD1L, ALC1, CHDL, chromodomain helicase DNA binding protein 1-like, chromodomain helicase DNA binding protein 1 like
External IDs MGI: 1915308 HomoloGene: 11590 GeneCards: CHD1L
RNA expression pattern
PBB GE CHD1L 207645 s at fs.png

PBB GE CHD1L 212539 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001256336
NM_001256337
NM_001256338
NM_004284
NM_024568

NM_026539

RefSeq (protein)

NP_080815.1
NP_080815

Location (UCSC) Chr 1: 147.24 – 147.3 Mb Chr 3: 97.56 – 97.61 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Chromodomain-helicase-DNA-binding protein 1-like is an enzyme that in humans is encoded by the CHD1L gene.[3][4] It has been implicated in chromatin remodeling and DNA relaxation process required for DNA replication, repair and transcription.


Related gene problems[edit]

With 1q21.1 deletion syndrome a disturbance occurs, which leads to increased DNA breaks. The role of CHD1L is similar to that of helicase with the Werner syndrome[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Mao M, Fu G, Wu JS, Zhang QH, Zhou J, Kan LX, Huang QH, He KL, Gu BW, Han ZG, Shen Y, Gu J, Yu YP, Xu SH, Wang YX, Chen SJ, Chen Z (Aug 1998). "Identification of genes expressed in human CD34+ hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning". Proc Natl Acad Sci U S A. 95 (14): 8175–80. doi:10.1073/pnas.95.14.8175. PMC 20949Freely accessible. PMID 9653160. 
  4. ^ "Entrez Gene: CHD1L chromodomain helicase DNA binding protein 1-like". 
  5. ^ Understanding the impact of 1q21.1 Copy Number Variant; C. Harvard et al; Orphanet Journal of Rare Diseases 2011, 6:54; doi:10.1186/1750-1172-6-54

External links[edit]

Further reading[edit]