CHKA

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CHKA
Protein CHKA PDB 2cko.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CHKA, CHK, CK, CKI, EK, choline kinase alpha
External IDs MGI: 107760 HomoloGene: 88575 GeneCards: CHKA
EC number 2.7.1.82
RNA expression pattern
PBB GE CHKA 204266 s at fs.png

PBB GE CHKA 204233 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001277
NM_212469

NM_001025566
NM_001271496
NM_013490

RefSeq (protein)

NP_001268
NP_997634

NP_001258425.1
NP_038518.2
NP_001258425
NP_038518

Location (UCSC) Chr 11: 68.05 – 68.12 Mb Chr 19: 3.85 – 3.89 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Choline kinase alpha is an enzyme that in humans is encoded by the CHKA gene.[3][4][5]

The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also catalyzes the phosphorylation of ethanolamine. Two transcript variants encoding different isoforms have been found for this gene.[5]

In melanocytic cells CHKA gene expression may be regulated by MITF.[6]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Hosaka K, Tanaka S, Nikawa J, Yamashita S (Aug 1992). "Cloning of a human choline kinase cDNA by complementation of the yeast cki mutation". FEBS Lett. 304 (2–3): 229–32. doi:10.1016/0014-5793(92)80625-Q. PMID 1618328. 
  4. ^ Aoyama C, Liao H, Ishidate K (Mar 2004). "Structure and function of choline kinase isoforms in mammalian cells". Prog Lipid Res. 43 (3): 266–81. doi:10.1016/j.plipres.2003.12.001. PMID 15003397. 
  5. ^ a b "Entrez Gene: CHKA choline kinase alpha". 
  6. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. 

External links[edit]

Further reading[edit]