CHKB (gene)

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Protein CHKB PDB 2ig7.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases CHKB, CHETK, CHKL, CK, CKB, CKEKB, EK, EKB, MDCMC, choline kinase beta
External IDs MGI: 1328313 HomoloGene: 88718 GeneCards: CHKB
RNA expression pattern
PBB GE CHKB 204193 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 22: 50.58 – 50.6 Mb Chr 15: 89.42 – 89.43 Mb
PubMed search [1] [2]
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Choline kinase beta is a protein encoded by the CHKB gene.[3][4] This gene is found on chromosome 22 in humans.[5]

Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. At least two transcript variants encoding two different isoforms have been found for this gene, and one of the transcripts is bicistronic.[5]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Yamazaki N, Yamanaka Y, Hashimoto Y, Shinohara Y, Shima A, Terada H (June 1997). "Structural features of the gene encoding human muscle type carnitine palmitoyltransferase I". FEBS Lett. 409 (3): 401–6. doi:10.1016/S0014-5793(97)00561-9. PMID 9224698. 
  4. ^ Aoyama C, Liao H, Ishidate K (May 2004). "Structure and function of choline kinase isoforms in mammalian cells". Prog. Lipid Res. 43 (3): 266–81. doi:10.1016/j.plipres.2003.12.001. PMID 15003397. 
  5. ^ a b "Entrez Gene: CHKB choline kinase beta". 

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