CHML (gene)

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Aliases CHML, REP2, choroideremia-like (Rab escort protein 2), CHM like, Rab escort protein 2
External IDs MGI: 101913 HomoloGene: 31055 GeneCards: CHML
RNA expression pattern
PBB GE CHML 206079 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 1: 241.63 – 241.64 Mb Chr 1: 175.68 – 175.69 Mb
PubMed search [1] [2]
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Rab proteins geranylgeranyltransferase component A 2 is an enzyme that in humans is encoded by the CHML gene.[3][4]

The product of the CHML gene supports geranylgeranylation of most Rab proteins and may substitute for REP-1 in tissues other than retina. CHML is localized close to the gene for Usher syndrome type II.[4]


CHML (gene) has been shown to interact with RAB1A[5][6] and RAB5A.[5][6]


  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ van Bokhoven H, van den Hurk JA, Bogerd L, Philippe C, Gilgenkrantz S, de Jong P, Ropers HH, Cremers FP (January 1995). "Cloning and characterization of the human choroideremia gene". Hum Mol Genet. 3 (7): 1041–6. PMID 7981670. doi:10.1093/hmg/3.7.1041. 
  4. ^ a b "Entrez Gene: CHML choroideremia-like (Rab escort protein 2)". 
  5. ^ a b Anant, J S; Desnoyers L; Machius M; Demeler B; Hansen J C; Westover K D; Deisenhofer J; Seabra M C (September 1998). "Mechanism of Rab geranylgeranylation: formation of the catalytic ternary complex". Biochemistry. UNITED STATES. 37 (36): 12559–68. ISSN 0006-2960. PMID 9730828. doi:10.1021/bi980881a. 
  6. ^ a b Cremers, F P; Armstrong S A; Seabra M C; Brown M S; Goldstein J L (January 1994). "REP-2, a Rab escort protein encoded by the choroideremia-like gene". J. Biol. Chem. UNITED STATES. 269 (3): 2111–7. ISSN 0021-9258. PMID 8294464. 

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