Cholinergic receptor, nicotinic, alpha 1

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Cholinergic receptor, nicotinic, alpha 1 (muscle)
Protein CHRNA1 PDB 1Y5P.png
Rendering based on PDB 1Y5P.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM100690 MGI87885 HomoloGene59 IUPHAR: 462 ChEMBL: 4808 GeneCards: CHRNA1 Gene
RNA expression pattern
PBB GE CHRNA1 206633 at tn.png
More reference expression data
Species Human Mouse
Entrez 1134 11435
Ensembl ENSG00000138435 ENSMUSG00000027107
UniProt P02708 P04756
RefSeq (mRNA) NM_000079 NM_007389
RefSeq (protein) NP_000070 NP_031415
Location (UCSC) Chr 2:
175.61 – 175.63 Mb
Chr 2:
73.56 – 73.58 Mb
PubMed search [1] [2]

Acetylcholine receptor subunit alpha is a protein that in humans is encoded by the CHRNA1 gene.[1]

The muscle acetylcholine receptor consists of 5 subunits of 4 different types: 2 alpha isoforms and 1 each of beta, gamma, and delta subunits.2 This gene encodes an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified.[1]


Cholinergic receptor, nicotinic, alpha 1 has been shown to interact with CHRND.[2][3]

See also[edit]


  1. ^ a b "Entrez Gene: CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle)". 
  2. ^ Kreienkamp, H J; Maeda R K; Sine S M; Taylor P (March 1995). "Intersubunit contacts governing assembly of the mammalian nicotinic acetylcholine receptor". Neuron (UNITED STATES) 14 (3): 635–44. doi:10.1016/0896-6273(95)90320-8. ISSN 0896-6273. PMID 7695910. 
  3. ^ Wang, Z Z; Hardy S F; Hall Z W (November 1996). "Assembly of the nicotinic acetylcholine receptor. The first transmembrane domains of truncated alpha and delta subunits are required for heterodimer formation in vivo". J. Biol. Chem. (UNITED STATES) 271 (44): 27575–84. doi:10.1074/jbc.271.44.27575. ISSN 0021-9258. PMID 8910344. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.