CHRNA1

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CHRNA1
Protein CHRNA1 PDB 1Y5P.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CHRNA1, ACHRA, ACHRD, CHRNA, CMS2A, FCCMS, SCCMS, CMS1A, CMS1B, Cholinergic receptor, nicotinic, alpha 1, cholinergic receptor nicotinic alpha 1 subunit
External IDs MGI: 87885 HomoloGene: 59 GeneCards: CHRNA1
RNA expression pattern
PBB GE CHRNA1 206633 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001039523
NM_000079

NM_007389

RefSeq (protein)

NP_000070
NP_001034612

NP_031415.2
NP_031415

Location (UCSC) Chr 2: 174.75 – 174.79 Mb Chr 2: 73.56 – 73.58 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Neuronal acetylcholine receptor subunit alpha-1, also known as nAChRα1, is a protein that in humans is encoded by the CHRNA1 gene.[3] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

The muscle acetylcholine receptor consists of 5 subunits of 4 different types: 2 alpha isoforms and 1 each of beta, gamma, and delta subunits.2 This gene encodes an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]

Interactions[edit]

Cholinergic receptor, nicotinic, alpha 1 has been shown to interact with CHRND.[4][5]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle)". 
  4. ^ Kreienkamp, H J; Maeda R K; Sine S M; Taylor P (March 1995). "Intersubunit contacts governing assembly of the mammalian nicotinic acetylcholine receptor". Neuron. UNITED STATES. 14 (3): 635–44. doi:10.1016/0896-6273(95)90320-8. ISSN 0896-6273. PMID 7695910. 
  5. ^ Wang, Z Z; Hardy S F; Hall Z W (November 1996). "Assembly of the nicotinic acetylcholine receptor. The first transmembrane domains of truncated alpha and delta subunits are required for heterodimer formation in vivo". J. Biol. Chem. UNITED STATES. 271 (44): 27575–84. doi:10.1074/jbc.271.44.27575. ISSN 0021-9258. PMID 8910344. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.