CHRNA1

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CHRNA1
Protein CHRNA1 PDB 1Y5P.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCHRNA1, ACHRA, ACHRD, CHRNA, CMS2A, FCCMS, SCCMS, CMS1A, CMS1B, Cholinergic receptor, nicotinic, alpha 1, cholinergic receptor nicotinic alpha 1 subunit
External IDsMGI: 87885 HomoloGene: 59 GeneCards: CHRNA1
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for CHRNA1
Genomic location for CHRNA1
Band2q31.1Start174,747,592 bp[1]
End174,787,935 bp[1]
RNA expression pattern
PBB GE CHRNA1 206633 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001039523
NM_000079

NM_007389

RefSeq (protein)

NP_000070
NP_001034612

NP_031415

Location (UCSC)Chr 2: 174.75 – 174.79 MbChr 2: 73.56 – 73.58 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuronal acetylcholine receptor subunit alpha-1, also known as nAChRα1, is a protein that in humans is encoded by the CHRNA1 gene.[5] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

The muscle acetylcholine receptor consists of 5 subunits of 4 different types: 2 alpha isoforms and 1 each of beta, gamma, and delta subunits.2 This gene encodes an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified.[5]

Interactions[edit]

Cholinergic receptor, nicotinic, alpha 1 has been shown to interact with CHRND.[6][7]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138435 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027107 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle)".
  6. ^ Kreienkamp, H J; Maeda R K; Sine S M; Taylor P (March 1995). "Intersubunit contacts governing assembly of the mammalian nicotinic acetylcholine receptor". Neuron. 14 (3): 635–44. doi:10.1016/0896-6273(95)90320-8. ISSN 0896-6273. PMID 7695910.
  7. ^ Wang, Z Z; Hardy S F; Hall Z W (November 1996). "Assembly of the nicotinic acetylcholine receptor. The first transmembrane domains of truncated alpha and delta subunits are required for heterodimer formation in vivo". J. Biol. Chem. 271 (44): 27575–84. doi:10.1074/jbc.271.44.27575. ISSN 0021-9258. PMID 8910344.

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.