CHRNA2

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CHRNA2
Identifiers
Aliases CHRNA2, cholinergic receptor nicotinic alpha 2 subunit
External IDs MGI: 87886 HomoloGene: 20193 GeneCards: CHRNA2
Gene location (Human)
Chromosome 8 (human)
Chr. Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for CHRNA2
Genomic location for CHRNA2
Band 8p21.2 Start 27,459,761 bp[1]
End 27,479,883 bp[1]
RNA expression pattern
PBB GE CHRNA2 207868 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_144803

RefSeq (protein)

NP_659052

Location (UCSC) Chr 8: 27.46 – 27.48 Mb Chr 8: 66.14 – 66.15 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neuronal acetylcholine receptor subunit alpha-2, also known as nAChRα2, is a protein that in humans is encoded by the CHRNA2 gene.[5][6] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

Function[edit]

Knockout of this gene in mice potentiates nicotine-modulated behaviors.[7] Using two different genetically modified mutant mouse lines (Chrna2L9'S/L9'S and Chrna2KO), findings highlight that α2* nAChRs influence hippocampus-dependent learning and memory and CA1 synaptic plasticity in adolescent mice. [8]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000120903 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022041 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Anand R, Lindstrom J (Sep 1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics. 13 (4): 962–7. PMID 1505988. doi:10.1016/0888-7543(92)90008-G. 
  6. ^ "Entrez Gene: CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)". 
  7. ^ Lotfipour S, Byun JS, Leach P, Fowler CD, Murphy NP, Kenny PJ, Gould TJ, Boulter J (May 2013). "Targeted Deletion of the Mouse α2 Nicotinic Acetylcholine Receptor Subunit Gene (Chrna2) Potentiates Nicotine-Modulated Behaviors". J. Neurosci. 33 (18): 7728–41. PMC 3831006Freely accessible. PMID 23637165. doi:10.1523/JNEUROSCI.4731-12.2013. 
  8. ^ Lotfipour S, Mojica C, Nakauchi S, Lipovsek M, Silverstein S, Cushman J, Tirtorahardjo J, Poulos A, Elgoyhen AB, Sumikawa K, Fanselow MS, Boulter J (May 2017). "α2* Nicotinic acetylcholine receptors influence hippocampus-dependent learning and memory in adolescent mice.". Learn Mem. 24 (6): 231–244. PMID 28507032. doi:10.1101/lm.045369.117. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.