CHRNA2

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CHRNA2
Identifiers
Aliases CHRNA2
External IDs MGI: 87886 HomoloGene: 20193 GeneCards: CHRNA2
Targeted by Drug
hexamethonium, mecamylamine[1]
RNA expression pattern
PBB GE CHRNA2 207868 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_144803

RefSeq (protein)

NP_659052.1
NP_659052

Location (UCSC) Chr 8: 27.46 – 27.48 Mb Chr 14: 66.14 – 66.15 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Neuronal acetylcholine receptor subunit alpha-2, also known as nAChRα2, is a protein that in humans is encoded by the CHRNA2 gene.[4][5] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).

Function[edit]

Knockout of this gene in mice potentiates nicotine-modulated behaviors.[6]

See also[edit]

References[edit]

  1. ^ "Drugs that physically interact with Cholinergic receptor nicotinic alpha 2 subunit view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ Anand R, Lindstrom J (Sep 1992). "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics. 13 (4): 962–7. doi:10.1016/0888-7543(92)90008-G. PMID 1505988. 
  5. ^ "Entrez Gene: CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal)". 
  6. ^ Lotfipour S, Byun JS, Leach P, Fowler CD, Murphy NP, Kenny PJ, Gould TJ, Boulter J (May 2013). "Targeted Deletion of the Mouse α2 Nicotinic Acetylcholine Receptor Subunit Gene (Chrna2) Potentiates Nicotine-Modulated Behaviors". J. Neurosci. 33 (18): 7728–41. doi:10.1523/JNEUROSCI.4731-12.2013. PMID 23637165. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.