CHRNA6

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CHRNA6
Identifiers
Aliases CHRNA6, CHNRA6, cholinergic receptor nicotinic alpha 6 subunit
External IDs MGI: 106213 HomoloGene: 20888 GeneCards: CHRNA6
Targeted by Drug
hexamethonium, mecamylamine[1]
RNA expression pattern
PBB GE CHRNA6 207568 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004198
NM_001199279

NM_021369

RefSeq (protein)

NP_001186208
NP_004189

NP_067344.2
NP_067344

Location (UCSC) Chr 8: 42.75 – 42.8 Mb Chr 8: 27.4 – 27.41 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Cholinergic receptor, nicotinic, alpha 6, also known as nAChRα6, is a protein that in humans is encoded by the CHRNA6 gene.[4] The CHRNA6 gene codes for the α6 nicotinic receptor subunit that is found in certain types of nicotinic acetylcholine receptors found primarily in the brain. Neural nicotinic acetylcholine receptors containing α6 subunits are expressed on dopamine-releasing neurons in the midbrain,[5] and dopamine release following activation of these neurons is thought to be involved in the addictive properties of nicotine.[6][7][8] Due to their selective localisation on dopaminergic neurons, α6-containing nACh receptors have also been suggested as a possible therapeutic target for the treatment of Parkinson's disease.[9][10]


Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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NicotineDopaminergic_WP1602 go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article go to article go to article go to article Go to article Go to article go to article Go to article Go to article Go to article go to article Go to article Go to article Go to article go to article go to article go to article go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article Go to article go to article Go to article Go to article go to article
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NicotineDopaminergic_WP1602 go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article Go to article go to article go to article go to article go to article Go to article Go to article go to article Go to article Go to article Go to article go to article Go to article Go to article Go to article go to article go to article go to article go to article go to article go to article Go to article go to article Go to article Go to article go to article go to article Go to article go to article Go to article Go to article go to article
|{{{bSize}}}px|alt=Nicotine Activity on Dopaminergic Neurons edit]]
Nicotine Activity on Dopaminergic Neurons edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602". 

See also[edit]

References[edit]

  1. ^ "Drugs that physically interact with Cholinergic receptor nicotinic alpha 6 subunit view/edit references on wikidata". 
  2. ^ "Human PubMed Reference:". 
  3. ^ "Mouse PubMed Reference:". 
  4. ^ "Entrez Gene: CHRNA6 cholinergic receptor, nicotinic, alpha 6". 
  5. ^ Meyer EL, Yoshikami D, McIntosh JM (2008). "The Neuronal Nicotinic Acetylcholine Receptors α4* and α6* Differentially Modulate Dopamine Release in Mouse Striatal Slices". Journal of Neurochemistry. 105 (5): 1761–9. doi:10.1111/j.1471-4159.2008.05266.x. PMC 2527994Freely accessible. PMID 18248619. 
  6. ^ Calabresi P, Massimiliano D (Oct 2008). "ACh/Dopamine Crosstalk in Motor Control and Reward: A Crucial Role for α6-Containing Nicotinic Receptors?". Neuron. 60 (1): 4–7. doi:10.1016/j.neuron.2008.09.031. PMID 18940582. 
  7. ^ Drenan RM, Grady SR, Whiteaker P, McClure-Begley T, McKinney S, Miwa JM, Bupp S, Heintz N, et al. (2008). "In vivo activation of midbrain dopamine neurons via sensitized, high-affinity alpha 6 nicotinic acetylcholine receptors". Neuron. 60 (1): 123–36. doi:10.1016/j.neuron.2008.09.009. PMC 2632732Freely accessible. PMID 18940593. 
  8. ^ Exley R, Clements MA, Hartung H, McIntosh JM, Cragg SJ (2008). "Alpha6-containing nicotinic acetylcholine receptors dominate the nicotine control of dopamine neurotransmission in nucleus accumbens". Neuropsychopharmacology. 33 (9): 2158–66. doi:10.1038/sj.npp.1301617. PMID 18033235. 
  9. ^ Quik M, McIntosh JM (2006). "Striatal alpha6* nicotinic acetylcholine receptors: potential targets for Parkinson's disease therapy". The Journal of Pharmacology and Experimental Therapeutics. 316 (2): 481–9. doi:10.1124/jpet.105.094375. PMID 16210393. 
  10. ^ Bordia T, Grady SR, McIntosh JM, Quik M (2007). "Nigrostriatal damage preferentially decreases a subpopulation of alpha6beta2* nAChRs in mouse, monkey, and Parkinson's disease striatum". Molecular Pharmacology. 72 (1): 52–61. doi:10.1124/mol.107.035998. PMID 17409284. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.