CHRNB1

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CHRNB1
Identifiers
Aliases CHRNB1, ACHRB, CHRNB, CMS1D, CMS2A, SCCMS, CMS2C, cholinergic receptor nicotinic beta 1 subunit
External IDs MGI: 87890 HomoloGene: 594 GeneCards: CHRNB1
Gene location (Human)
Chromosome 17 (human)
Chr. Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for CHRNB1
Genomic location for CHRNB1
Band 17p13.1 Start 7,445,061 bp[1]
End 7,457,707 bp[1]
RNA expression pattern
PBB GE CHRNB1 206703 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000747

NM_009601

RefSeq (protein)

NP_000738

NP_033731

Location (UCSC) Chr 17: 7.45 – 7.46 Mb Chr 17: 69.78 – 69.8 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Acetylcholine receptor subunit beta is a protein that in humans is encoded by the CHRNB1 gene.[5]

The muscle acetylcholine receptor is composed of five subunits: two alpha subunits and one beta, one gamma, and one delta subunit. This gene encodes the beta subunit of the acetylcholine receptor. The acetylcholine receptor changes conformation upon acetylcholine binding leading to the opening of an ion-conducting channel across the plasma membrane. Mutations in this gene are associated with slow-channel congenital myasthenic syndrome.[5]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.