The station was founded in 1965 by A. Raymond Crepault, owner of CJMS Montreal. CJRS (the "RS" stood for Radio Sherbrooke) commenced broadcasting in August 1967. Its broadcast parameters are currently unknown, though its coverage was restricted at night to protect Class-A clear-channel station WLAC in Nashville, Tennessee.
In 1991, CJRS applied to the CRTC for permission to discontinue local programming in favour of carrying only programming produced for the parent Radiomutuel network, or programs originating from CJMS through December 1992.  In 1993, the CRTC approved an extension of this arrangement through August 31, 1995; however, as it no longer produced local programming, CJRS was banned from selling advertising in the Sherbrooke area.
On September 30, 1994, Telemedia and Radiomutuel merged their AM operations because they could no longer afford to compete with each other. As a result, they closed CJRS, along with CJMS Montreal, CJRP Quebec City, CJMT Chicoutimi, CJTR Trois-Rivieres and CKCH Hull. All six stations left the air on this date and the licenses were turned in to the CRTC, which revoked the licences on November 2, 1994. 
- Decision CRTC 85-421, CJRS Radio-Média Inc. CRTC, June 6, 1985
- ARCHIVED - Decision CRTC 87-83, CRTC, February 12, 1987 (see September 12, 1986)
- Decision CRTC 91-863, CRTC, December 2, 1991
- Decision CRTC 93-10, CRTC, January 12, 1993
- Decision CRTC 94-845, Revocation of CJRS Sherbrooke, Quebec, November 2, 1994