CKAP2

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CKAP2
Identifiers
AliasesCKAP2, LB1, TMAP, se20-10, cytoskeleton associated protein 2
External IDsMGI: 1931797 HomoloGene: 10070 GeneCards: CKAP2
Gene location (Human)
Chromosome 13 (human)
Chr.Chromosome 13 (human)[1]
Chromosome 13 (human)
Genomic location for CKAP2
Genomic location for CKAP2
Band13q14.3Start52,455,429 bp[1]
End52,476,628 bp[1]
RNA expression pattern
PBB GE CKAP2 218252 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001098525
NM_001286686
NM_001286687
NM_018204

NM_001004140

RefSeq (protein)

NP_001091995
NP_001273615
NP_001273616
NP_060674

NP_001004140

Location (UCSC)Chr 13: 52.46 – 52.48 MbChr 8: 22.17 – 22.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Cytoskeleton-associated protein 2 is a protein that in humans is encoded by the CKAP2 gene.[5][6]

Human CKAP2 gene, the cDNA of which is known as LB1, is a cytoskeleton-associated protein involved in mitotic progression. Its high transcriptional activity has been observed in the testes, thymus, and diffuse B-cell lymphomas. The gene codes for a protein of 683 residues, which lacks a homology to known amino acid sequences. On evidence of immunofluorescence analysis, the CKAP2 product is a cytoplasmic protein associated with cytoskeletal fibrils. The CKAP2 gene is in chromosome 13q14. Rearrangements of this region result in various tumors. Thus deletions have been detected in multiple myeloma, prostate cancer, head-and-neck squamous-cell carcinoma, B-cell prolymphocytic leukemia, non-Hodgkin lymphoma, and in more than half cases of B-cell chronic lymphocytic leukemia.


References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136108 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037725 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Maouche-Chretien L, Deleu N, Badoual C, Fraissignes P, Berger R, Gaulard P, Romeo PH, Leroy-Viard K (Oct 1998). "Identification of a novel cDNA, encoding a cytoskeletal associated protein, differentially expressed in diffuse large B cell lymphomas". Oncogene. 17 (10): 1245–51. doi:10.1038/sj.onc.1202048. PMID 9771967.
  6. ^ "Entrez Gene: CKAP2 cytoskeleton associated protein 2".

Alternative titles: TUMOR- AND MICROTUBLE-ASSOCIATED PROTEIN; TMAP, LB1

External links[edit]

Further reading[edit]