CKMT2

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CKMT2
Protein CKMT2 PDB 2gl6.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CKMT2, SMTCK, creatine kinase, mitochondrial 2
External IDs MGI: 1923972 HomoloGene: 68206 GeneCards: CKMT2
Gene location (Human)
Chromosome 5 (human)
Chr. Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for CKMT2
Genomic location for CKMT2
Band 5q14.1 Start 81,233,285 bp[1]
End 81,266,397 bp[1]
RNA expression pattern
PBB GE CKMT2 205295 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001825
NM_001099735
NM_001099736

NM_198415

RefSeq (protein)

NP_940807

Location (UCSC) Chr 5: 81.23 – 81.27 Mb Chr 5: 91.85 – 91.88 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Creatine kinase S-type, mitochondrial is an enzyme that in humans is encoded by the CKMT2 gene.[5][6]

Mitochondrial creatine kinase (MtCK) is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. The "energy-rich" gamma-phosphate group of ATP that is generated by oxidative phosphorylation inside mitochondria is trans-phosphorylated to creatine (Cr) to give phospho-creatine (PCr), which then is exported from the mitochondria into the cytosol, where it is made available to cytosolic creatine kinases (CK) for in situ regeneration of the ATP that has been used for cellular work. Cr then is returning to the mitochondria where it stimulates mitochondrial respiration and again is charged-up by mitochondrial ATP via MtCK. This process is termed the PCr/Cr-shuttle or circuit. MtCK belongs to the creatine kinase (CK) isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Sarcomeric mitochondrial creatine kinase has 80% homology with the coding exons of ubiquitous mitochondrial creatine kinase. This gene contains sequences homologous to several motifs that are shared among some nuclear genes encoding mitochondrial proteins and thus may be essential for the coordinated activation of these genes during mitochondrial biogenesis.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000131730 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021622 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Haas RC, Strauss AW (May 1990). "Separate nuclear genes encode sarcomere-specific and ubiquitous human mitochondrial creatine kinase isoenzymes". J Biol Chem. 265 (12): 6921–7. PMID 2324105. 
  6. ^ a b "Entrez Gene: CKMT2 creatine kinase, mitochondrial 2 (sarcomeric)". 

External links[edit]

Further reading[edit]