CLASP1

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CLASP1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CLASP1, MAST1, cytoplasmic linker associated protein 1
External IDs MGI: 1923957 HomoloGene: 41024 GeneCards: CLASP1
RNA expression pattern
PBB GE CLASP1 212752 at fs.png

PBB GE CLASP1 gnf1h03925 s at fs.png

PBB GE CLASP1 gnf1h03920 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001142273
NM_001142274
NM_001207051
NM_015282

NM_001081276
NM_001293300
NM_001293301
NM_029709
NM_177548

RefSeq (protein)

NP_001135745
NP_001135746
NP_001193980
NP_056097

Location (UCSC) Chr 2: 121.34 – 121.65 Mb Chr 1: 118.39 – 118.61 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Cytoplasmic linker associated protein 1, also known as CLASP1, is a protein which in humans is encoded by the CLASP1 gene.[3]

Function[edit]

CLASP1 belongs to a family of microtubule-associated proteins involved in attachment of microtubules to the cell cortex in animals[4] and plants.[5] CLASPs, such as CLASP1, interact with CLIPs (e.g., CLIP1). In animal cells, CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle.[3][6] CLASP1 controls the interactions of astral microtubules with the cell cortex in mitosis, which is important for the proper positioning and orientation of the spindle.[7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: CLASP1 cytoplasmic linker associated protein 1". 
  4. ^ Lansbergen G, Grigoriev I, Mimori-Kiyosue Y, et al. (2006). "CLASPs attach microtubule plus ends to the cell cortex through a complex with LL5beta". Developmental Cell. 11 (1): 21–32. doi:10.1016/j.devcel.2006.05.012. PMID 16824950. 
  5. ^ Ambrose JC, Wasteneys GO (2008). "CLASP Modulates Microtubule-Cortex Interaction during Self-Organization of Acentrosomal Microtubules". Molecular Biology of the Cell. 19 (11): 4730–4737. doi:10.1091/mbc.E08-06-0665. PMC 2575154Freely accessible. PMID 18716054. 
  6. ^ Maiato H, Fairley EA, Rieder CL, Swedlow JR, Sunkel CE, Earnshaw WC (June 2003). "Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics". Cell. 113 (7): 891–904. doi:10.1016/S0092-8674(03)00465-3. PMID 12837247. 
  7. ^ Samora, Catarina P.; Mogessie, Binyam; Conway, Leslie; Ross, Jennifer L.; Straube, Anne; McAinsh, Andrew D. (7 August 2011). "MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis". Nature Cell Biology. 13 (9): 1040–1050. doi:10.1038/ncb2297. PMID 21822276. 

External links[edit]

Further reading[edit]