Chloride channel accessory 1 is a protein that in humans is encoded by the CLCA1gene.
This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine. Protein structure prediction methods suggest the N-terminal region of CLCA1 protein is a zinc metalloprotease.
^Gruber AD, Elble RC, Ji HL, Schreur KD, Fuller CM, Pauli BU (Jan 1999). "Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl− channel proteins". Genomics. 54 (2): 200–14. doi:10.1006/geno.1998.5562. PMID9828122.
^Pawłowski K, Lepistö M, Meinander N, et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins. 63 (3): 424–39. doi:10.1002/prot.20887. PMID16470849.
Agnel M, Vermat T, Culouscou JM (1999). "Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea". FEBS Lett. 455 (3): 295–301. doi:10.1016/S0014-5793(99)00891-1. PMID10437792.
Toda M, Tulic MK, Levitt RC, Hamid Q (2002). "A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma". J. Allergy Clin. Immunol. 109 (2): 246–50. doi:10.1067/mai.2002.121555. PMID11842292.
Greenwood IA, Miller LJ, Ohya S, Horowitz B (2002). "The large conductance potassium channel beta-subunit can interact with and modulate the functional properties of a calcium-activated chloride channel, CLCA1". J. Biol. Chem. 277 (25): 22119–22. doi:10.1074/jbc.C200215200. PMID11994272.
Abdel-Ghany M, Cheng HC, Elble RC, Pauli BU (2002). "Focal adhesion kinase activated by beta(4) integrin ligation to mCLCA1 mediates early metastatic growth". J. Biol. Chem. 277 (37): 34391–400. doi:10.1074/jbc.M205307200. PMID12110680.
Loewen ME, Bekar LK, Gabriel SE, et al. (2002). "pCLCA1 becomes a cAMP-dependent chloride conductance mediator in Caco-2 cells". Biochem. Biophys. Res. Commun. 298 (4): 531–6. doi:10.1016/S0006-291X(02)02498-1. PMID12408984.
Zhou Y, Shapiro M, Dong Q, et al. (2003). "A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction". Novartis Found. Symp. 248: 150–65; discussion 165–70, 277–82. doi:10.1002/0470860790.ch10. PMID12568493.
Abdel-Ghany M, Cheng HC, Elble RC, et al. (2004). "The interacting binding domains of the beta(4) integrin and calcium-activated chloride channels (CLCAs) in metastasis". J. Biol. Chem. 278 (49): 49406–16. doi:10.1074/jbc.M309086200. PMID14512419.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Ritzka M, Stanke F, Jansen S, et al. (2005). "The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis". Hum. Genet. 115 (6): 483–91. doi:10.1007/s00439-004-1190-y. PMID15490240.
Gibson A, Lewis AP, Affleck K, et al. (2005). "hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels". J. Biol. Chem. 280 (29): 27205–12. doi:10.1074/jbc.M504654200. PMID15919655.
Jeong SM, Park HK, Yoon IS, et al. (2005). "Cloning and expression of Ca2+-activated chloride channel from rat brain". Biochem. Biophys. Res. Commun. 334 (2): 569–76. doi:10.1016/j.bbrc.2005.06.122. PMID16023076.