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Chloride channel accessory 1
Symbols CLCA1 ; CACC; CACC1; CLCRG1; CaCC-1; GOB5; hCLCA1; hCaCC-1
External IDs OMIM603906 MGI1346342 HomoloGene984 GeneCards: CLCA1 Gene
RNA expression pattern
PBB GE CLCA1 210107 at tn.png
More reference expression data
Species Human Mouse
Entrez 1179 23844
Ensembl ENSG00000016490 ENSMUSG00000028255
UniProt A8K7I4 Q9D7Z6
RefSeq (mRNA) NM_001285 NM_017474
RefSeq (protein) NP_001276 NP_059502
Location (UCSC) Chr 1:
86.47 – 86.5 Mb
Chr 3:
145 – 145.03 Mb
PubMed search [1] [2]

Chloride channel accessory 1 is a protein that in humans is encoded by the CLCA1 gene.[1][2]

This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.[2] Protein structure prediction methods suggest the N-terminal region of CLCA1 protein is a zinc metalloprotease.[3]

See also[edit]


  1. ^ Gruber AD, Elble RC, Ji HL, Schreur KD, Fuller CM, Pauli BU (Jan 1999). "Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl channel proteins". Genomics 54 (2): 200–14. doi:10.1006/geno.1998.5562. PMID 9828122. 
  2. ^ a b "Entrez Gene: CLCA1 chloride channel, calcium activated, family member 1". 
  3. ^ Pawłowski K, Lepistö M, Meinander N; et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins 63 (3): 424–39. doi:10.1002/prot.20887. PMID 16470849. 

Further reading[edit]

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.