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Aliases CLCA3P, CLCA3, chloride channel accessory 3, pseudogene
External IDs GeneCards: CLCA3P
Gene location (Human)
Chromosome 1 (human)
Chr. Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for CLCA3P
Genomic location for CLCA3P
Band 1p22.3 Start 86,634,273 bp[1]
End 86,655,376 bp[1]
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 1: 86.63 – 86.66 Mb n/a
PubMed search [2] n/a
View/Edit Human

Chloride channel accessory 3, also known as CLCA3, is a protein which in humans is encoded by the CLCA3P pseudogene. The protein encoded by this gene is a chloride channel.[3] This protein is not expressed in humans but is in certain other species such as mouse.


This gene is a transcribed pseudogene belonging to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. This gene contains several nonsense codons compared to other family members that render the transcript a candidate for nonsense-mediated mRNA decay (NMD), although this gene is translated into a well characterized protein which has been shown to decorate mucin granule containing vesicles. Protein structure prediction methods suggest the N-terminal region of CLCA3 protein is a zinc metalloprotease, and the protein is not an ion channel per se.[4]

See also[edit]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000153923 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ Gruber AD, Pauli BU (March 1999). "Molecular cloning and biochemical characterization of a truncated, secreted member of the human family of Ca2+-activated Cl channels". Biochim. Biophys. Acta. 1444 (3): 418–23. doi:10.1016/S0167-4781(99)00008-1. PMID 10095065. 
  4. ^ Pawłowski K, Lepistö M, Meinander N, et al. (2006). "Novel conserved hydrolase domain in the CLCA family of alleged calcium-activated chloride channels". Proteins. 63 (3): 424–39. doi:10.1002/prot.20887. PMID 16470849. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.